InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PVRL1

Summary

InnateDB Protein

IDBP-74537.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PVRL1

Protein Name

poliovirus receptor-related 1 (herpesvirus entry mediator C)

Synonyms

CD111; CLPED1; ED4; HIgR; HV1S; HVEC; nectin-1; OFC7; PRR; PRR1; PVRR; PVRR1; SK-12;

Species

Homo sapiens

Ensembl Protein

ENSP00000264025

InnateDB Gene

IDBG-74533 (PVRL1)

Protein Structure

UniProt Annotation

Function

Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between PVRL1/nectin-1 and PVRL3/nectin-3 and between PVRL1/nectin-1 and PVRL4/nectin-4. Functions as an entry receptor for herpes simplex virus and pseudorabies virus. Has some neurite outgrowth-promoting activity. {ECO:0000269PubMed:21980294, ECO:0000269PubMed:7721102}.

Subcellular Localization

Isoform Alpha: Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, presynaptic cell membrane {ECO:0000250}.Isoform Delta: Cell membrane; Single-pass type I membrane protein.Isoform Gamma: Secreted.

Disease Associations

Ectodermal dysplasia, Margarita Island type (EDMI) [MIM:225060]: An autosomal recessive form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. It is a syndrome characterized by the association of cleft lip/palate, ectodermal dysplasia (sparse short and dry scalp hair, sparse eyebrows and eyelashes), and partial syndactyly of the fingers and/or toes. Two thirds of the patients do not manifest oral cleft but present with abnormal teeth and nails. Note=The disease is caused by mutations affecting the gene represented in this entry.Non-syndromic orofacial cleft 7 (OFC7) [MIM:225060]: A birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001618	virus receptor activity
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0015026	coreceptor activity
GO:0030246	carbohydrate binding
GO:0042803	protein homodimerization activity
GO:0046790	virion binding
GO:0046982	protein heterodimerization activity
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0002089	lens morphogenesis in camera-type eye
GO:0002934	desmosome organization
GO:0006826	iron ion transport
GO:0006955	immune response
GO:0007155	cell adhesion
GO:0007156	homophilic cell adhesion
GO:0007157	heterophilic cell-cell adhesion
GO:0007165	signal transduction
GO:0007411	axon guidance
GO:0009615	response to virus
GO:0016337	single organismal cell-cell adhesion
GO:0034329	cell junction assembly
GO:0034332	adherens junction organization
GO:0045216	cell-cell junction organization
GO:0046718	viral entry into host cell
GO:0048593	camera-type eye morphogenesis
GO:0051963	regulation of synapse assembly
GO:0060041	retina development in camera-type eye
GO:0070166	enamel mineralization

Cellular Component

GO:0005576	extracellular region
GO:0005886	plasma membrane
GO:0005912	adherens junction
GO:0005913	cell-cell adherens junction
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016342	catenin complex
GO:0030424	axon
GO:0032584	growth cone membrane
GO:0042734	presynaptic membrane
GO:0043005	neuron projection
GO:0043231	intracellular membrane-bounded organelle
GO:0045202	synapse

Protein Structure and Domains

PDB ID

InterPro

IPR003596 Immunoglobulin V-set, subgroup
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
IPR013162 CD80-like, immunoglobulin C2-set

PFAM

PF07686
PF00047
PF08205

PRINTS

PIRSF

SMART

SM00406
SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q15223