Version 5.4
Homo sapiens Gene: PVRL1
Summary
InnateDB Gene IDBG-74533.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PVRL1
Gene Name poliovirus receptor-related 1 (herpesvirus entry mediator C)
Synonyms CD111; CLPED1; ED4; HIgR; HV1S; HVEC; nectin-1; OFC7; PRR; PRR1; PVRR; PVRR1; SK-12
Species Homo sapiens
Ensembl Gene ENSG00000110400
Encoded Proteins
IDBP-74535
poliovirus receptor-related 1 (herpesvirus entry mediator C)
IDBP-74537
poliovirus receptor-related 1 (herpesvirus entry mediator C)
IDBP-74539
poliovirus receptor-related 1 (herpesvirus entry mediator C)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:119623408-119729084
Strand Reverse strand
Band q23.3
Transcripts
ENST00000341398 ENSP00000344974
ENST00000264025 ENSP00000264025
ENST00000340882 ENSP00000345289
ENST00000531468
ENST00000524429
ENST00000532197
ENST00000524510
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001618 virus receptor activity
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0015026 coreceptor activity
GO:0030246 carbohydrate binding
GO:0042803 protein homodimerization activity
GO:0046790 virion binding
GO:0046982 protein heterodimerization activity
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0002089 lens morphogenesis in camera-type eye
GO:0002934 desmosome organization
GO:0006826 iron ion transport
GO:0006955 immune response
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion
GO:0007157 heterophilic cell-cell adhesion
GO:0007165 signal transduction
GO:0007411 axon guidance
GO:0009615 response to virus
GO:0016337 single organismal cell-cell adhesion
GO:0034329 cell junction assembly
GO:0034332 adherens junction organization
GO:0045216 cell-cell junction organization
GO:0046718 viral entry into host cell
GO:0048593 camera-type eye morphogenesis
GO:0051963 regulation of synapse assembly
GO:0060041 retina development in camera-type eye
GO:0070166 enamel mineralization
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005912 adherens junction
GO:0005913 cell-cell adherens junction
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016342 catenin complex
GO:0030424 axon
GO:0032584 growth cone membrane
GO:0042734 presynaptic membrane
GO:0043005 neuron projection
GO:0043231 intracellular membrane-bounded organelle
GO:0045202 synapse
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032012
View Gene Order
ENSBTAG00000015939
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_19268
Nectin/Necl trans heterodimerization pathway
REACT_19195
Adherens junctions interactions pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
REACT_19331
Cell-cell junction organization pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa04520
Adherens junction pathway
INOH
PID NCI
nectin_pathway
Nectin adhesion pathway
Cross-References
SwissProt Q15223
TrEMBL Q6SYC0 Q6SYC2
UniProt Splice Variant
Entrez Gene 5818
UniGene Hs.334846 Hs.618202
RefSeq NM_002855 NM_203285 NM_203286
HUGO HGNC:9706
OMIM 600644
CCDS CCDS8425 CCDS8426 CCDS8427
HPRD
IMGT
EMBL AF060231 AF196768 AF196769 AF196770 AF196771 AF196772 AF196773 AF196774 AF252867 AY029539 AY445577 AY445578 AY445580 AY445581 BC104948 BC113471 X76400
GenPept AAC23798 AAG16648 AAG16649 AAI04949 AAI13472 AAK33124 AAR88250 AAR88252 CAA53980
RNA Seq Atlas 5818

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca