Version 5.4
Homo sapiens Protein: NETO2
Summary
InnateDB Protein IDBP-745833.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NETO2
Protein Name
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000455169
InnateDB Gene IDBG-29497 (NETO2)
Protein Structure
UniProt Annotation
Function Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus directly influencing synaptic transmission (By similarity). {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0035255 ionotropic glutamate receptor binding
Biological Process
GO:2000312 regulation of kainate selective glutamate receptor activity
Cellular Component
GO:0014069 postsynaptic density
GO:0032983 kainate selective glutamate receptor complex
GO:0045202 synapse
Protein Structure and Domains
PDB ID
InterPro IPR000859 CUB domain
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
PFAM PF00431
PF00057
PRINTS PR00261
PIRSF
SMART SM00042
SM00192
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NC67
PhosphoSite PhosphoSite-Q8NC67
TrEMBL
UniProt Splice Variant
Entrez Gene 81831
UniGene Hs.730937
RefSeq NP_060562
HUGO HGNC:14644
OMIM 607974
CCDS CCDS10727
HPRD 09721
IMGT
EMBL AC007338 AC007494 AK001292 AK027478 AK027630 AK074937 AL834404 AY358718 BC012381 BX538063 CR457255
GenPept AAH12381 AAQ89080 BAA91604 BAB55141 BAB55247 BAC11303 CAD39066 CAD97994 CAG33536

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca