InnateDB Protein
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IDBP-746672.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CDIPT
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Protein Name
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Synonyms
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PIS; PIS1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000457339
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InnateDB Gene
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IDBG-24907 (CDIPT)
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Protein Structure
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Function |
Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme. {ECO:0000269PubMed:8110188}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Membrane {ECO:0000269PubMed:8110188}.
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Disease Associations |
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Tissue Specificity |
Detected in placenta (at protein level). Widely expressed. Higher expression in adult liver and skeletal muscle, slightly lower levels seen in pancreas, kidney, lung, placenta, brain, heart, leukocyte, colon, small intestine, ovary, testis, prostate, thymus and spleen. In fetus, expressed in kidney, liver, lung and brain. {ECO:0000269PubMed:8110188}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
21
[view]
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Protein-Protein |
20
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0003881
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CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity
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GO:0016780
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phosphotransferase activity, for other substituted phosphate groups
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000462
CDP-alcohol phosphatidyltransferase
IPR014387
CDP-diacylglycerol-inositol 3-phosphatidyltransferase, eukaryote
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PFAM |
PF01066
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PRINTS |
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PIRSF |
PIRSF000848
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O14735
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PhosphoSite |
PhosphoSite-O14735
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TrEMBL |
B3KSW0
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UniProt Splice Variant |
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Entrez Gene |
10423
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UniGene |
Hs.743785
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RefSeq |
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HUGO |
HGNC:1769
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OMIM |
605893
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CCDS |
CCDS10657
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HPRD |
12063
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IMGT |
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EMBL |
AC120114
AF014807
AK094468
AK097691
AK131349
AK290632
AK300805
BC001444
BT007301
CH471238
CR542016
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GenPept |
AAB94860
AAH01444
AAP35965
BAD18505
BAF83321
BAG52872
BAG53514
BAG62462
CAG46813
EAW79976
EAW79977
EAW79978
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