Version 5.4
Homo sapiens Gene: CDIPT
Summary
InnateDB Gene IDBG-24907.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDIPT
Gene Name CDP-diacylglycerol--inositol 3-phosphatidyltransferase
Synonyms PIS; PIS1
Species Homo sapiens
Ensembl Gene ENSG00000103502
Encoded Proteins
IDBP-24909
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
IDBP-751532
IDBP-754372
IDBP-751215
IDBP-748857
IDBP-746672
IDBP-747641
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Phosphatidylinositol breakdown products are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. Two enzymes, CDP-diacylglycerol synthase and phosphatidylinositol synthase, are involved in the biosynthesis of phosphatidylinositol. Phosphatidylinositol synthase, a member of the CDP-alcohol phosphatidyl transferase class-I family, is an integral membrane protein found on the cytoplasmic side of the endoplasmic reticulum and the Golgi apparatus. [provided by RefSeq, Jul 2008]
Phosphatidylinositol breakdown products are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. Two enzymes, CDP-diacylglycerol synthase and phosphatidylinositol synthase, are involved in the biosynthesis of phosphatidylinositol. Phosphatidylinositol synthase, a member of the CDP-alcohol phosphatidyl transferase class-I family, is an integral membrane protein found on the cytoplasmic side of the endoplasmic reticulum and the Golgi apparatus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:29858357-29863736
Strand Reverse strand
Band p11.2
Transcripts
ENST00000219789 ENSP00000219789
ENST00000570016 ENSP00000454453
ENST00000563893
ENST00000564296 ENSP00000457207
ENST00000566113 ENSP00000457340
ENST00000561555 ENSP00000455042
ENST00000562041
ENST00000569956 ENSP00000457339
ENST00000567459
ENST00000563415 ENSP00000457766
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 21 [view]
Protein-Protein 20 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003881 CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity
GO:0016740 transferase activity
GO:0016780 phosphotransferase activity, for other substituted phosphate groups
GO:0019992 diacylglycerol binding
GO:0030145 manganese ion binding
GO:0030246 carbohydrate binding
GO:0043178 alcohol binding
Biological Process
GO:0006644 phospholipid metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0008152 metabolic process
GO:0008654 phospholipid biosynthetic process
GO:0044281 small molecule metabolic process
GO:0046341 CDP-diacylglycerol metabolic process
GO:0046474 glycerophospholipid biosynthetic process
Cellular Component
GO:0000139 Golgi membrane
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030682
View Gene Order
ENSBTAG00000007954
Not yet available
Pathways
NETPATH
REACTOME
REACT_121000
Synthesis of PI pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121401
Glycerophospholipid biosynthesis pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00562
Inositol phosphate metabolism pathway
hsa00564
Glycerophospholipid metabolism pathway
hsa04070
Phosphatidylinositol signaling system pathway
INOH
PID NCI
Cross-References
SwissProt O14735
TrEMBL
UniProt Splice Variant
Entrez Gene 10423
UniGene Hs.731127 Hs.743785
RefSeq NM_001286585 NM_001286586 NM_006319 XM_005255038
HUGO HGNC:1769
OMIM 605893
CCDS CCDS67002 CCDS10657
HPRD 12063
IMGT
EMBL AC120114 AF014807 AK131349 AK300805 BC001444 BT007301 CR542016
GenPept AAB94860 AAH01444 AAP35965 BAD18505 BAG62462 CAG46813
RNA Seq Atlas 10423

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca