Version 5.4
Homo sapiens Protein: DHODH
Summary
InnateDB Protein IDBP-750907.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DHODH
Protein Name
Synonyms DHOdehase; POADS; URA1;
Species Homo sapiens
Ensembl Protein ENSP00000461848
InnateDB Gene IDBG-41409 (DHODH)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004152 dihydroorotate dehydrogenase activity
GO:0004158 dihydroorotate oxidase activity
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006222 UMP biosynthetic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR005719 Dihydroorotate dehydrogenase, class 2
IPR012135 Dihydroorotate dehydrogenase, class 1/ 2
PFAM PF01180
PRINTS
PIRSF PIRSF000164
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL J3QRQ3
UniProt Splice Variant
Entrez Gene 1723
UniGene Hs.654427
RefSeq
HUGO HGNC:2867
OMIM 126064
CCDS
HPRD 00521
IMGT
EMBL AC009087 AC009127
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca