InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DHODH

Summary

InnateDB Gene

IDBG-41409.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DHODH

Gene Name

dihydroorotate dehydrogenase (quinone)

Synonyms

DHOdehase; POADS; URA1

Species

Homo sapiens

Ensembl Gene

ENSG00000102967

Encoded Proteins

IDBP-41411

dihydroorotate dehydrogenase (quinone)

IDBP-751736

IDBP-751395

IDBP-750907

IDBP-751905

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:72008588-72027664

Strand

Forward strand

Band

q22.2

Transcripts

ENST00000219240	ENSP00000219240
ENST00000573922
ENST00000576145	ENSP00000464333
ENST00000571392
ENST00000571288	ENSP00000464249
ENST00000572887	ENSP00000461848
ENST00000574309	ENSP00000460966
ENST00000573843
ENST00000572003

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004152	dihydroorotate dehydrogenase activity
GO:0004158	dihydroorotate oxidase activity
GO:0008144	drug binding
GO:0010181	FMN binding
GO:0048039	ubiquinone binding

Biological Process

GO:0006206	pyrimidine nucleobase metabolic process
GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process
GO:0006222	UMP biosynthetic process
GO:0007565	female pregnancy
GO:0007595	lactation
GO:0014070	response to organic cyclic compound
GO:0031000	response to caffeine
GO:0042493	response to drug
GO:0042594	response to starvation
GO:0043065	positive regulation of apoptotic process
GO:0044205	'de novo' UMP biosynthetic process
GO:0044281	small molecule metabolic process
GO:0046134	pyrimidine nucleoside biosynthetic process
GO:0055086	nucleobase-containing small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:0090140	regulation of mitochondrial fission

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043025	neuronal cell body

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000031730

View Gene Order

ENSBTAG00000019887

Not yet available

Pathways

NETPATH

REACTOME

REACT_21376

Pyrimidine biosynthesis pathway

REACT_1698

Metabolism of nucleotides pathway

REACT_957

Pyrimidine metabolism pathway

REACT_111217

Metabolism pathway

KEGG

hsa00240

Pyrimidine metabolism pathway

INOH

INOH website

Pyrimidine nucleotides nucleosides metabolism pathway

PID NCI

Cross-References

SwissProt

Q02127

TrEMBL

I3NI32 J3QRQ3

UniProt Splice Variant

Entrez Gene

1723

UniGene

Hs.654427

RefSeq

NM_001361

HUGO

HGNC:2867

OMIM

126064

CCDS

CCDS42192

HPRD

IMGT

EMBL

AC009087 AC009127 AK292293 BC065245 M94065

GenPept

AAA50163 AAH65245 BAF84982

RNA Seq Atlas

1723