InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ITGA6

Summary

InnateDB Protein

IDBP-75106.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITGA6

Protein Name

integrin, alpha 6

Synonyms

CD49f; ITGA6B; VLA-6;

Species

Homo sapiens

Ensembl Protein

ENSP00000264107

InnateDB Gene

IDBG-75102 (ITGA6)

Protein Structure

UniProt Annotation

Function

Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. {ECO:0000269PubMed:17303120}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:22314500}; Single-pass type I membrane protein {ECO:0000269PubMed:22314500}. Cell membrane {ECO:0000269PubMed:22314500}; Lipid-anchor {ECO:0000269PubMed:22314500}.

Disease Associations

Epidermolysis bullosa letalis, with pyloric atresia (EB- PA) [MIM:226730]: An autosomal recessive, frequently lethal, epidermolysis bullosa with variable involvement of skin, nails, mucosa, and with variable effects on the digestive system. It is characterized by mucocutaneous fragility, aplasia cutis congenita, and gastrointestinal atresia, which most commonly affects the pylorus. Pyloric atresia is a primary manifestation rather than a scarring process secondary to epidermolysis bullosa. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney). {ECO:0000269PubMed:7681434}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	15 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0007044	cell-substrate junction assembly
GO:0007229	integrin-mediated signaling pathway
GO:0007596	blood coagulation
GO:0030198	extracellular matrix organization
GO:0031581	hemidesmosome assembly
GO:0031589	cell-substrate adhesion
GO:0034329	cell junction assembly
GO:0042327	positive regulation of phosphorylation
GO:0043065	positive regulation of apoptotic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050900	leukocyte migration
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0009986	cell surface

Protein Structure and Domains

PDB ID

InterPro

IPR000413 Integrin alpha chain
IPR013517 FG-GAP repeat
IPR013519 Integrin alpha beta-propellor
IPR013649 Integrin alpha-2
IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site

PFAM

PF01839
PF14312
PF08441
PF00357

PRINTS

PR01185

PIRSF

SMART

SM00191

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt