InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TSC2

Summary

InnateDB Protein

IDBP-751272.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TSC2

Protein Name

Synonyms

LAM; PPP1R160; TSC4;

Species

Homo sapiens

Ensembl Protein

ENSP00000454487

InnateDB Gene

IDBG-9819 (TSC2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 115 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	115 [view]
Protein-Protein	112 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005488	binding

Biological Process

GO:0032007	negative regulation of TOR signaling
GO:0043547	positive regulation of GTPase activity
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005737	cytoplasm
GO:0033596	TSC1-TSC2 complex

Protein Structure and Domains

PDB ID

InterPro

IPR000331 Rap GTPase activating protein domain
IPR003913 Tuberin
IPR016024 Armadillo-type fold
IPR018515 Tuberin-type domain
IPR024584 Tuberin, N-terminal

PFAM

PF02145
PF03542
PF11864

PRINTS

PR01431

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite