InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDIPT

Summary

InnateDB Protein

IDBP-751532.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDIPT

Protein Name

Synonyms

PIS; PIS1;

Species

Homo sapiens

Ensembl Protein

ENSP00000454453

InnateDB Gene

IDBG-24907 (CDIPT)

Protein Structure

UniProt Annotation

Function

Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme. {ECO:0000269PubMed:8110188}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Membrane {ECO:0000269PubMed:8110188}.

Disease Associations

Tissue Specificity

Detected in placenta (at protein level). Widely expressed. Higher expression in adult liver and skeletal muscle, slightly lower levels seen in pancreas, kidney, lung, placenta, brain, heart, leukocyte, colon, small intestine, ovary, testis, prostate, thymus and spleen. In fetus, expressed in kidney, liver, lung and brain. {ECO:0000269PubMed:8110188}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	20 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003881	CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity
GO:0016780	phosphotransferase activity, for other substituted phosphate groups

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006661	phosphatidylinositol biosynthetic process
GO:0008654	phospholipid biosynthetic process
GO:0044281	small molecule metabolic process
GO:0046474	glycerophospholipid biosynthetic process