InnateDB Protein
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IDBP-75159.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CCDC6
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Protein Name
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coiled-coil domain containing 6
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Synonyms
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D10S170; H4; PTC; TPC; TST1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000263102
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InnateDB Gene
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IDBG-75157 (CCDC6)
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Protein Structure
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Function |
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Subcellular Localization |
Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000305}. Note=May be a cytoskeletal protein.
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Disease Associations |
Thyroid papillary carcinoma (TPC) [MIM:188550]: A common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving CCDC6 is found in thyroid papillary carcinomas. Inversion inv(10)(q11.2;q21) generates the RET/CCDC6 (PTC1) oncogene.
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Tissue Specificity |
Ubiquitously expressed.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
32
[view]
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Protein-Protein |
29
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR019152
Protein of unknown function DUF2046
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PFAM |
PF09755
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q16204
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PhosphoSite |
PhosphoSite-Q16204
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
8030
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UniGene |
Hs.591360
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RefSeq |
NP_005427
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HUGO |
HGNC:18782
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OMIM |
601985
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CCDS |
CCDS7257
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HPRD |
09064
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IMGT |
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EMBL |
AC023904
AC060231
AK292593
BC036757
BC064391
CH471083
M31213
S72869
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GenPept |
AAA36524
AAC60637
AAH36757
AAH64391
BAF85282
EAW54196
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