InnateDB Protein
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IDBP-751805.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MKL2
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Protein Name
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000460589
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InnateDB Gene
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IDBG-15207 (MKL2)
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Protein Structure
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Function |
Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation. {ECO:0000269PubMed:14565952}.
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Subcellular Localization |
Nucleus {ECO:0000250}.
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Disease Associations |
Note=A chromosomal aberration involving C11orf95 is found in 3 chondroid lipomas. Translocation t(11;16)(q13;p13) with C11orf95 produces a C11orf95-MKL2 fusion protein (PubMed:20607705). {ECO:0000269PubMed:20607705}.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
13
[view]
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Protein-Protein |
12
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
GO:0006351
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transcription, DNA-templated
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GO:0007517
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muscle organ development
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GO:0045844
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positive regulation of striated muscle tissue development
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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Cellular Component |
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PDB ID |
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InterPro |
IPR004018
RPEL repeat
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PFAM |
PF02755
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PRINTS |
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PIRSF |
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SMART |
SM00707
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TIGRFAMs |
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Modification |
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SwissProt |
Q9ULH7
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PhosphoSite |
PhosphoSite-Q9ULH7
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
57496
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UniGene |
Hs.715910
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RefSeq |
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HUGO |
HGNC:29819
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OMIM |
609463
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CCDS |
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HPRD |
17577
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IMGT |
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EMBL |
AB033069
AC012626
AC040173
AC130650
AK093577
AK294765
AY374297
BC047761
BC136260
BC171750
CH471112
CR749797
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GenPept |
AAH47761
AAI36261
AAI71750
AAQ82435
BAA86557
BAC04200
BAG57899
CAH18657
EAW85112
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