InnateDB Protein
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IDBP-752204.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CNOT1
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Protein Name
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Synonyms
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CDC39; NOT1; NOT1H;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000455635
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InnateDB Gene
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IDBG-34466 (CNOT1)
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Protein Structure
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Function |
Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA- mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem (ES) cell identity. {ECO:0000269PubMed:10637334, ECO:0000269PubMed:16778766, ECO:0000269PubMed:21278420, ECO:0000269PubMed:21976065, ECO:0000269PubMed:21984185, ECO:0000269PubMed:22367759, ECO:0000269PubMed:23644599}.
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Subcellular Localization |
Cytoplasm, P-body {ECO:0000269PubMed:21976065}. Nucleus {ECO:0000305PubMed:21976065}. Note=NANOS2 promotes its localization to P-body. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Strongly expressed in brain, heart, thymus, spleen, kidney, liver, placenta and lung. Weakly expressed in skeletal muscle and colon. {ECO:0000269PubMed:10637334}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated |
Total |
58
[view]
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Protein-Protein |
58
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
5 [view]
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Molecular Function |
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0000288
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nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
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GO:0000289
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nuclear-transcribed mRNA poly(A) tail shortening
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GO:0006351
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transcription, DNA-templated
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GO:0006417
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regulation of translation
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GO:0007275
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multicellular organismal development
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GO:0010467
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gene expression
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GO:0010606
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positive regulation of cytoplasmic mRNA processing body assembly
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GO:0016070
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RNA metabolic process
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GO:0016071
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mRNA metabolic process
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GO:0031047
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gene silencing by RNA
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GO:0033147
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negative regulation of intracellular estrogen receptor signaling pathway
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GO:0048387
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negative regulation of retinoic acid receptor signaling pathway
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GO:0060213
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positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
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GO:0090503
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RNA phosphodiester bond hydrolysis, exonucleolytic
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GO:1900153
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positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
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GO:2000036
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regulation of stem cell maintenance
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Cellular Component |
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PDB ID |
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InterPro |
IPR007196
CCR4-Not complex component, Not1, C-terminal
IPR016024
Armadillo-type fold
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PFAM |
PF04054
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
A5YKK6
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PhosphoSite |
PhosphoSite-A5YKK6
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TrEMBL |
H3BT18
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UniProt Splice Variant |
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Entrez Gene |
23019
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UniGene |
Hs.742212
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RefSeq |
NP_001252541
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HUGO |
HGNC:7877
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OMIM |
604917
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CCDS |
CCDS58468
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HPRD |
11999
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IMGT |
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EMBL |
AB023224
AC009118
AC010287
AF110778
AK092885
AK301092
AL117492
BC000779
BC024317
BC040523
BX537840
CR749237
EF553522
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GenPept |
AAF14861
AAH00779
AAH24317
AAH40523
ABQ66268
BAA76851
BAG52622
BAH13408
CAB55960
CAD97851
CAH18093
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