Version 5.4
Homo sapiens Protein: SIAE
Summary
InnateDB Protein IDBP-75229.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SIAE
Protein Name sialic acid acetylesterase
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000263593
InnateDB Gene IDBG-75227 (SIAE)
Protein Structure
UniProt Annotation
Function Catalyzes the removal of O-acetyl ester groups from position 9 of the parent sialic acid, N-acetylneuraminic acid.
Subcellular Localization Lysosome {ECO:0000305}. Secreted.
Disease Associations Autoimmune disease 6 (AIS6) [MIM:613551]: Individuals manifesting susceptibility to autoimmune disease type 6 can suffer from juvenile idiopathic arthritis, rheumatoid arthritis, multiple sclerosis, Sjogren syndrome, systemic lupus erythematosus, type 1 diabetes, ulcerative colitis, and Crohn disease. {ECO:0000269PubMed:20555325}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Tissue Specificity Widely expressed with high expression in the testis, prostate, and colon. {ECO:0000269PubMed:15292578}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001681 sialate O-acetylesterase activity
Biological Process
GO:0002682 regulation of immune system process
GO:0005975 carbohydrate metabolic process
Cellular Component
GO:0005615 extracellular space
GO:0005764 lysosome
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR005181 Domain of unknown function DUF303, acetylesterase putative
PFAM PF03629
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9HAT2
PhosphoSite PhosphoSite-Q9HAT2
TrEMBL
UniProt Splice Variant
Entrez Gene 54414
UniGene Hs.674805
RefSeq NP_733746
HUGO HGNC:18187
OMIM 610079
CCDS CCDS8449
HPRD 16764
IMGT
EMBL AF300796 AF303378 AK056093 AL137496 BC068450 CH471065
GenPept AAG14897 AAG15386 AAH68450 BAG51622 CAB70771 EAW67591

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca