InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLCG1

Summary

InnateDB Protein

IDBP-75242.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLCG1

Protein Name

phospholipase C, gamma 1

Synonyms

NCKAP3; PLC-II; PLC1; PLC148; PLCgamma1;

Species

Homo sapiens

Ensembl Protein

ENSP00000362368

InnateDB Gene

IDBG-75238 (PLCG1)

Protein Structure

UniProt Annotation

Function

Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand- mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration. {ECO:0000269PubMed:17229814}.

Subcellular Localization

Cell projection, lamellipodium. Cell projection, ruffle. Note=Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 237 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	237 [view]
Protein-Protein	236 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004629	phospholipase C activity
GO:0004871	signal transducer activity
GO:0005057	receptor signaling protein activity
GO:0005168	neurotrophin TRKA receptor binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008081	phosphoric diester hydrolase activity
GO:0019901	protein kinase binding

Biological Process

GO:0000186	activation of MAPKK activity
GO:0006629	lipid metabolic process
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0007411	axon guidance
GO:0007596	blood coagulation
GO:0008152	metabolic process
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0009395	phospholipid catabolic process
GO:0010634	positive regulation of epithelial cell migration
GO:0016032	viral process
GO:0016477	cell migration
GO:0019221	cytokine-mediated signaling pathway
GO:0019722	calcium-mediated signaling
GO:0035556	intracellular signal transduction
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043536	positive regulation of blood vessel endothelial cell migration
GO:0043647	inositol phosphate metabolic process
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response
GO:0045766	positive regulation of angiogenesis
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0050852	T cell receptor signaling pathway
GO:0050900	leukocyte migration
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
GO:0071364	cellular response to epidermal growth factor stimulus

Cellular Component

GO:0001726	ruffle
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0008180	COP9 signalosome
GO:0030027	lamellipodium
GO:0042995	cell projection

Protein Structure and Domains

PDB ID

InterPro

IPR000008 C2 domain
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR000980 SH2 domain
IPR001192 Phosphoinositide phospholipase C family
IPR001452 SH3 domain
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR001849 Pleckstrin homology domain
IPR002048 EF-hand domain
IPR011511 Variant SH3 domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR016279 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain

PFAM