InnateDB Protein
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IDBP-75263.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CDCA7
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Protein Name
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cell division cycle associated 7
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000306968
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InnateDB Gene
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IDBG-75261 (CDCA7)
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Protein Structure
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Function |
Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator. {ECO:0000269PubMed:11598121, ECO:0000269PubMed:15994934, ECO:0000269PubMed:16580749, ECO:0000269PubMed:23166294}.
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Subcellular Localization |
Nucleus. Cytoplasm. Note=Predominantly nuclear with some expression also seen in the cytoplasm. Predominantly cytoplasmic when phosphorylated at Thr-163.
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Disease Associations |
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Tissue Specificity |
Ubiquitous with higher level in thymus and small intestine. Overexpressed in a large number of tumors, in blood from patients with acute myelogenous leukemia (AML) and in chronic myelogenous leukemia (CML) blast crisis. {ECO:0000269PubMed:11598121, ECO:0000269PubMed:15994934}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR018866
Zinc-finger domain of monoamine-oxidase A repressor R1
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PFAM |
PF10497
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BWT1
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PhosphoSite |
PhosphoSite-Q9BWT1
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TrEMBL |
B4DM13
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UniProt Splice Variant |
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Entrez Gene |
83879
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UniGene |
Hs.630838
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RefSeq |
NP_114148
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HUGO |
HGNC:14628
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OMIM |
609937
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CCDS |
CCDS2252
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HPRD |
09874
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IMGT |
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EMBL |
AC092573
AK027628
AK027642
AK075134
AK223524
AK297097
AK297245
AK300949
AL833728
AL834186
AY029179
BC015124
BC027966
BG354580
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GenPept |
AAH15124
AAH27966
AAK31591
AAX82003
BAB55245
BAB55258
BAC11425
BAD97244
BAG59610
BAG59725
BAG62578
CAH56253
CAH56357
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