Version 5.4
Homo sapiens Protein: CDCA7
Summary
InnateDB Protein IDBP-75265.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDCA7
Protein Name cell division cycle associated 7
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000272789
InnateDB Gene IDBG-75261 (CDCA7)
Protein Structure
UniProt Annotation
Function Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator. {ECO:0000269PubMed:11598121, ECO:0000269PubMed:15994934, ECO:0000269PubMed:16580749, ECO:0000269PubMed:23166294}.
Subcellular Localization Nucleus. Cytoplasm. Note=Predominantly nuclear with some expression also seen in the cytoplasm. Predominantly cytoplasmic when phosphorylated at Thr-163.
Disease Associations
Tissue Specificity Ubiquitous with higher level in thymus and small intestine. Overexpressed in a large number of tumors, in blood from patients with acute myelogenous leukemia (AML) and in chronic myelogenous leukemia (CML) blast crisis. {ECO:0000269PubMed:11598121, ECO:0000269PubMed:15994934}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006915 apoptotic process
GO:0042127 regulation of cell proliferation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR018866 Zinc-finger domain of monoamine-oxidase A repressor R1
PFAM PF10497
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BWT1
PhosphoSite PhosphoSite-Q9BWT1
TrEMBL B4DM13
UniProt Splice Variant
Entrez Gene 83879
UniGene Hs.630838
RefSeq NP_665809
HUGO HGNC:14628
OMIM 609937
CCDS CCDS2253
HPRD 09874
IMGT
EMBL AC092573 AK027628 AK027642 AK075134 AK223524 AK297097 AK297245 AK300949 AL833728 AL834186 AY029179 BC015124 BC027966 BG354580
GenPept AAH15124 AAH27966 AAK31591 AAX82003 BAB55245 BAB55258 BAC11425 BAD97244 BAG59610 BAG59725 BAG62578 CAH56253 CAH56357

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca