Version 5.4
Homo sapiens Protein: SECISBP2
Summary
InnateDB Protein IDBP-75338.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SECISBP2
Protein Name SECIS binding protein 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000364965
InnateDB Gene IDBG-75336 (SECISBP2)
Protein Structure
UniProt Annotation
Function Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations Abnormal thyroid hormone metabolism (ATHYHM) [MIM:609698]: A disorder associated with a reduction in type II iodothyronine deiodinase activity. {ECO:0000269PubMed:16228000}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Expressed at high levels in testis. {ECO:0000269PubMed:12095701}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003730 mRNA 3'-UTR binding
GO:0005515 protein binding
GO:0035368 selenocysteine insertion sequence binding
GO:0043021 ribonucleoprotein complex binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0030529 ribonucleoprotein complex
Protein Structure and Domains
PDB ID
InterPro IPR004038 Ribosomal protein L7Ae/L30e/S12e/Gadd45
IPR029064 50S ribosomal protein L30e-like
PFAM PF01248
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96T21
PhosphoSite PhosphoSite-Q96T21
TrEMBL Q9H948
UniProt Splice Variant
Entrez Gene 79048
UniGene Hs.687936
RefSeq NP_076982
HUGO HGNC:30972
OMIM 607693
CCDS CCDS6683
HPRD 07408
IMGT
EMBL AF380995 AK023078 AK290182 AL136881 AL160054 AL929575 BC023142 BC036109 BX000356 BX648787 CH471089
GenPept AAH23142 AAH36109 AAK57518 BAB14393 BAF82871 CAB66815 CAH10382 CAI41358 CAI41364 CAI95386 CAI95388 CAI95792 CAI95793 EAW62763 EAW62764

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca