Version 5.4
Homo sapiens Gene: SECISBP2
Summary
InnateDB Gene IDBG-75336.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SECISBP2
Gene Name SECIS binding protein 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000187742
Encoded Proteins
IDBP-75338
SECIS binding protein 2
IDBP-75340
SECIS binding protein 2
IDBP-374794
SECIS binding protein 2
IDBP-374795
SECIS binding protein 2
IDBP-596981
SECIS binding protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. The gene described in this record encodes a nuclear protein that functions as a SECIS binding protein. Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:89318506-89359662
Strand Forward strand
Band q22.2
Transcripts
ENST00000375807 ENSP00000364965
ENST00000339901 ENSP00000364959
ENST00000425851 ENSP00000414288
ENST00000440898 ENSP00000411573
ENST00000470305
ENST00000477484
ENST00000498819
ENST00000496597
ENST00000534113 ENSP00000436650
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003730 mRNA 3'-UTR binding
GO:0005515 protein binding
GO:0035368 selenocysteine insertion sequence binding
GO:0043021 ribonucleoprotein complex binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0030529 ribonucleoprotein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035139
View Gene Order
ENSBTAG00000001939
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.59804 Hs.623632 Hs.687936
RefSeq NM_001282688 NM_001282689 NM_001282690 NM_024077 XM_005252198 XM_005252202 XM_006717282
HUGO
OMIM
CCDS CCDS65076 CCDS65077 CCDS6683
HPRD 07408
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca