Homo sapiens Gene: SECISBP2
Summary
InnateDB Gene IDBG-75336.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SECISBP2
Gene Name SECIS binding protein 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000187742
Encoded Proteins
SECIS binding protein 2
SECIS binding protein 2
SECIS binding protein 2
SECIS binding protein 2
SECIS binding protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. The gene described in this record encodes a nuclear protein that functions as a SECIS binding protein. Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:89318506-89359662
Strand Forward strand
Band q22.2
Transcripts
ENST00000375807 ENSP00000364965
ENST00000339901 ENSP00000364959
ENST00000425851 ENSP00000414288
ENST00000440898 ENSP00000411573
ENST00000470305
ENST00000477484
ENST00000498819
ENST00000496597
ENST00000534113 ENSP00000436650
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003730 mRNA 3'-UTR binding
GO:0005515 protein binding
GO:0035368 selenocysteine insertion sequence binding
GO:0043021 ribonucleoprotein complex binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0030529 ribonucleoprotein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL F8W892 Q7L1Z0 Q9H948
UniProt Splice Variant
Entrez Gene 79048
UniGene Hs.59804 Hs.623632 Hs.687936
RefSeq NM_001282690 XM_005252198 XM_005252202 NM_001282688 NM_001282689 NM_024077 XM_006717282
HUGO HGNC:30972
OMIM 607693
CCDS CCDS65077 CCDS65076 CCDS6683
HPRD 07408
IMGT
EMBL AK023078 AL160054 AL929575 BC023142 BX000356
GenPept AAH23142 BAB14393
RNA Seq Atlas 79048