InnateDB Protein
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IDBP-75340.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SECISBP2
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Protein Name
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SECIS binding protein 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000364959
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InnateDB Gene
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IDBG-75336 (SECISBP2)
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Protein Structure
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Function |
Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB.
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Subcellular Localization |
Nucleus {ECO:0000305}.
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Disease Associations |
Abnormal thyroid hormone metabolism (ATHYHM) [MIM:609698]: A disorder associated with a reduction in type II iodothyronine deiodinase activity. {ECO:0000269PubMed:16228000}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Expressed at high levels in testis. {ECO:0000269PubMed:12095701}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004038
Ribosomal protein L7Ae/L30e/S12e/Gadd45
IPR029064
50S ribosomal protein L30e-like
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PFAM |
PF01248
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96T21
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PhosphoSite |
PhosphoSite-Q96T21
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TrEMBL |
Q9H948
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UniProt Splice Variant |
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Entrez Gene |
79048
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UniGene |
Hs.687936
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RefSeq |
NP_001269618
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HUGO |
HGNC:30972
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OMIM |
607693
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CCDS |
CCDS65076
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HPRD |
07408
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IMGT |
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EMBL |
AF380995
AK023078
AK290182
AL136881
AL160054
AL929575
BC023142
BC036109
BX000356
CH471089
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GenPept |
AAH23142
AAH36109
AAK57518
BAB14393
BAF82871
CAB66815
CAI41358
CAI41364
CAI95386
CAI95388
CAI95792
CAI95793
EAW62763
EAW62764
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