Version 5.4
Homo sapiens Protein: DOK4
Summary
InnateDB Protein IDBP-753511.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DOK4
Protein Name
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000455128
InnateDB Gene IDBG-33376 (DOK4)
Protein Structure
UniProt Annotation
Function DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells. {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity Widely expressed. High expression in skeletal muscle, heart, kidney and liver. Weaker expression in spleen, lung and small intestine, brain, heart and. Expressed in both resting and activated peripheral blood T-cells. {ECO:0000269PubMed:12595900, ECO:0000269PubMed:12730241}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005158 insulin receptor binding
GO:0005515 protein binding
Biological Process
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR001849 Pleckstrin homology domain
IPR002404 Insulin receptor substrate-1, PTB
PFAM PF00169
PF02174
PRINTS PR00628
PIRSF
SMART SM00233
SM00310
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TEW6
PhosphoSite PhosphoSite-Q8TEW6
TrEMBL H3BVB4
UniProt Splice Variant
Entrez Gene 55715
UniGene Hs.279832
RefSeq
HUGO HGNC:19868
OMIM 608333
CCDS CCDS10783
HPRD 16316
IMGT
EMBL AC004382 AC009052 AF466369 AK001350 BC001540 BC003541 CH471092
GenPept AAC24310 AAH01540 AAH03541 AAL74195 BAA91642 EAW82932 EAW82933 EAW82934

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca