InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GSPT1

Summary

InnateDB Protein

IDBP-753589.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GSPT1

Protein Name

Synonyms

551G9.2; eRF3a; ETF3A; GST1;

Species

Homo sapiens

Ensembl Protein

ENSP00000454351

InnateDB Gene

IDBG-15002 (GSPT1)

Protein Structure

UniProt Annotation

Function

Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the activity of ERF1. Involved in regulation of mammalian cell growth. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	37 [view]
Protein-Protein	36 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003747	translation release factor activity
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006184	GTP catabolic process
GO:0006415	translational termination
GO:0006479	protein methylation

Cellular Component

GO:0005622

intracellular

Protein Structure and Domains

PDB ID

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR004160 Translation elongation factor EFTu/EF1A, C-terminal
IPR004161 Translation elongation factor EFTu/EF1A, domain 2
IPR009000 Translation protein, beta-barrel domain
IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00009
PF03143
PF03144

PRINTS

PR00315

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P15170