InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATP5G3

Summary

InnateDB Protein

IDBP-75633.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP5G3

Protein Name

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)

Synonyms

P3;

Species

Homo sapiens

Ensembl Protein

ENSP00000284727

InnateDB Gene

IDBG-75631 (ATP5G3)

Protein Structure

UniProt Annotation

Function

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.

Subcellular Localization

Mitochondrion membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0008289	lipid binding
GO:0015078	hydrogen ion transmembrane transporter activity

Biological Process

GO:0015986	ATP synthesis coupled proton transport
GO:0015991	ATP hydrolysis coupled proton transport

Cellular Component

GO:0005739	mitochondrion
GO:0005753	mitochondrial proton-transporting ATP synthase complex
GO:0016021	integral component of membrane
GO:0033177	proton-transporting two-sector ATPase complex, proton-transporting domain
GO:0045263	proton-transporting ATP synthase complex, coupling factor F(o)