Version 5.4
Homo sapiens Protein: PELP1
Summary
InnateDB Protein IDBP-758696.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PELP1
Protein Name
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000461625
InnateDB Gene IDBG-19211 (PELP1)
Protein Structure
UniProt Annotation
Function Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence- specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Involved in nuclear receptor signaling via its interaction with AR and NR3C1. May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. {ECO:0000269PubMed:11481323, ECO:0000269PubMed:12415108, ECO:0000269PubMed:12682072, ECO:0000269PubMed:14963108, ECO:0000269PubMed:15374949, ECO:0000269PubMed:15456770, ECO:0000269PubMed:15579769, ECO:0000269PubMed:15994929, ECO:0000269PubMed:16140940, ECO:0000269PubMed:16352611, ECO:0000269PubMed:16574651, ECO:0000269PubMed:22872859}.
Subcellular Localization Nucleus, nucleoplasm {ECO:0000250}. Nucleus. Cytoplasm. Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasm (By similarity). Also found associated with the plasma membrane. Mainly in cytoplasm in a subset of breast tumors. Localization is widely deregulated in endometrial cancers with predominantly cytoplasm localization in high-grade endometrial tumors. {ECO:0000250}.
Disease Associations
Tissue Specificity Isoform 2 is expressed in breast cancer cell lines. Isoform 1 is widely expressed. {ECO:0000269PubMed:11481323}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 84 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 84 [view]
Protein-Protein 76 [view]
Protein-DNA 8 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006351 transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0071339 MLL1 complex
Protein Structure and Domains
PDB ID
InterPro IPR012980 Uncharacterised domain NUC202
IPR016024 Armadillo-type fold
PFAM PF08166
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IZL8
PhosphoSite PhosphoSite-Q8IZL8
TrEMBL I3L4P1
UniProt Splice Variant
Entrez Gene 27043
UniGene Hs.741234
RefSeq
HUGO HGNC:30134
OMIM 609455
CCDS
HPRD 10144
IMGT
EMBL AC091153 AF547989 AY882602 BC002875 BC010457 BC069058 U88153
GenPept AAC17708 AAH02875 AAH10457 AAH69058 AAN41255 AAW80659

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca