InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BIRC5

Summary

InnateDB Protein

IDBP-758974.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BIRC5

Protein Name

Synonyms

API4; EPR-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000466617

InnateDB Gene

IDBG-70554 (BIRC5)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 74 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004869	cysteine-type endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0008270	zinc ion binding
GO:0008536	Ran GTPase binding
GO:0015631	tubulin binding
GO:0019899	enzyme binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity
GO:0048037	cofactor binding
GO:0050897	cobalt ion binding
GO:0051087	chaperone binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0000910	cytokinesis
GO:0006351	transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0007059	chromosome segregation
GO:0007067	mitotic nuclear division
GO:0008284	positive regulation of cell proliferation
GO:0010951	negative regulation of endopeptidase activity
GO:0031503	protein complex localization
GO:0031536	positive regulation of exit from mitosis
GO:0031577	spindle checkpoint
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045931	positive regulation of mitotic cell cycle
GO:0051301	cell division
GO:0051303	establishment of chromosome localization

Cellular Component

GO:0000228	nuclear chromosome
GO:0000775	chromosome, centromeric region
GO:0000777	condensed chromosome kinetochore
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005814	centriole
GO:0005819	spindle
GO:0005829	cytosol
GO:0005874	microtubule
GO:0005876	spindle microtubule
GO:0005881	cytoplasmic microtubule
GO:0030496	midbody
GO:0031021	interphase microtubule organizing center
GO:0032133	chromosome passenger complex