InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRIM39

Summary

InnateDB Protein

IDBP-75927.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIM39

Protein Name

tripartite motif containing 39

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000365844

InnateDB Gene

IDBG-75923 (TRIM39)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1. {ECO:0000269PubMed:19100260, ECO:0000269PubMed:22529100}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000269PubMed:19100260}. Mitochondrion {ECO:0000269PubMed:19100260}. Note=Found predominantly in the cytosol. Partial shift from the cytosol to the mitochondria when colocalized with MOAP1.

Disease Associations

Tissue Specificity

Ubiquitous; highly expressed in brain, heart, kidney, liver, skeletal muscle, spleen and testis. {ECO:0000269PubMed:19100260}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.

Experimentally validated
Total	54 [view]
Protein-Protein	53 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0042802	identical protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006915	apoptotic process
GO:0016567	protein ubiquitination
GO:2000059	negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2001235	positive regulation of apoptotic signaling pathway

Cellular Component

GO:0005622	intracellular
GO:0005739	mitochondrion
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000315 Zinc finger, B-box
IPR001841 Zinc finger, RING-type
IPR001870 B30.2/SPRY domain
IPR003877 SPRY domain
IPR003879 Butyrophylin-like
IPR006574 SPRY-associated
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR018957 Zinc finger, C3HC4 RING-type

PFAM

PF00643
PF13639
PF14634
PF00622
PF13765
PF00097

PRINTS

PR01407

PIRSF

SMART

SM00336
SM00184
SM00449
SM00589

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt