InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SGK2

Summary

InnateDB Protein

IDBP-75940.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SGK2

Protein Name

serum/glucocorticoid regulated kinase 2

Synonyms

dJ138B7.2; H-SGK2;

Species

Homo sapiens

Ensembl Protein

ENSP00000362184

InnateDB Gene

IDBG-75934 (SGK2)

Protein Structure

UniProt Annotation

Function

Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up- regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. {ECO:0000269PubMed:12397388, ECO:0000269PubMed:12590200, ECO:0000269PubMed:12632189, ECO:0000269PubMed:12634932, ECO:0000269PubMed:15040001, ECO:0000269PubMed:20511718, ECO:0000269PubMed:21865597}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:21865597}. Nucleus {ECO:0000269PubMed:21865597}.

Disease Associations

Tissue Specificity

Highly expressed in liver, kidney and pancreas, and at lower levels in brain. {ECO:0000269PubMed:10548550}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	7 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0015459	potassium channel regulator activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017080	sodium channel regulator activity

Biological Process

GO:0001558	regulation of cell growth
GO:0006468	protein phosphorylation
GO:0006979	response to oxidative stress
GO:0032411	positive regulation of transporter activity
GO:0034220	ion transmembrane transport
GO:0035556	intracellular signal transduction
GO:0042127	regulation of cell proliferation
GO:0055085	transmembrane transport

Cellular Component

GO:0005575	cellular_component
GO:0005634	nucleus
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR017892 Protein kinase, C-terminal
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF00433

PRINTS

PR00109

PIRSF

SMART

SM00133
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt