InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BRIP1

Summary

InnateDB Protein

IDBP-759437.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BRIP1

Protein Name

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000464654

InnateDB Gene

IDBG-62607 (BRIP1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	28 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0004003	ATP-dependent DNA helicase activity
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0016817	hydrolase activity, acting on acid anhydrides
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0006200	ATP catabolic process
GO:0008152	metabolic process
GO:0032508	DNA duplex unwinding

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR002919 Trypsin Inhibitor-like, cysteine rich domain
IPR006554 Helicase-like, DEXD box c2 type
IPR006555 ATP-dependent helicase, C-terminal
IPR010614 DEAD2
IPR011545 DEAD/DEAH box helicase domain
IPR013020 DNA helicase (DNA repair), Rad3 type
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR014013 Helicase, superfamily 1/2, ATP-binding domain, DinG/Rad3-type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01826
PF13307
PF06733
PF00270

PRINTS

PIRSF

SMART

SM00488
SM00491
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite