Homo sapiens Gene: BRIP1
Summary
InnateDB Gene IDBG-62607.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BRIP1
Gene Name BRCA1 interacting protein C-terminal helicase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000136492
Encoded Proteins
BRCA1 interacting protein C-terminal helicase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). This gene may be a target of germline cancer-inducing mutations. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:61681266-61863521
Strand Reverse strand
Band q23.2
Transcripts
ENST00000259008 ENSP00000259008
ENST00000584322 ENSP00000463272
ENST00000583837
ENST00000577598 ENSP00000464654
ENST00000579028 ENSP00000463827
ENST00000577913 ENSP00000462274
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 32 [view]
Protein-Protein 28 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0004003 ATP-dependent DNA helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008026 ATP-dependent helicase activity
GO:0016817 hydrolase activity, acting on acid anhydrides
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0000077 DNA damage checkpoint
GO:0006139 nucleobase-containing compound metabolic process
GO:0006200 ATP catabolic process
GO:0006302 double-strand break repair
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0008152 metabolic process
GO:0032508 DNA duplex unwinding
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0031965 nuclear membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Homologous Recombination Repair pathway
Double-Strand Break Repair pathway
Cytosolic iron-sulfur cluster assembly pathway
Homologous DNA pairing and strand exchange pathway
Homologous recombination repair of replication-independent double-strand breaks pathway
Metabolism pathway
DNA Repair pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Fanconi anemia pathway
Cross-References
SwissProt
TrEMBL J3KS24
UniProt Splice Variant
Entrez Gene 83990
UniGene Hs.128903
RefSeq NM_032043
HUGO HGNC:20473
OMIM 605882
CCDS CCDS11631
HPRD 05797
IMGT
EMBL AC002994 AC005969 AC060798
GenPept
RNA Seq Atlas 83990