InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: BRIP1

Summary

InnateDB Gene

IDBG-62607.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BRIP1

Gene Name

BRCA1 interacting protein C-terminal helicase 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000136492

Encoded Proteins

IDBP-62609

BRCA1 interacting protein C-terminal helicase 1

IDBP-760783

IDBP-759437

IDBP-758008

IDBP-759477

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). This gene may be a target of germline cancer-inducing mutations. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:61681266-61863521

Strand

Reverse strand

Band

q23.2

Transcripts

ENST00000259008	ENSP00000259008
ENST00000584322	ENSP00000463272
ENST00000583837
ENST00000577598	ENSP00000464654
ENST00000579028	ENSP00000463827
ENST00000577913	ENSP00000462274

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	28 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0004003	ATP-dependent DNA helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0016817	hydrolase activity, acting on acid anhydrides
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0046872	metal ion binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0000077	DNA damage checkpoint
GO:0006139	nucleobase-containing compound metabolic process
GO:0006200	ATP catabolic process
GO:0006302	double-strand break repair
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0008152	metabolic process
GO:0032508	DNA duplex unwinding
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0031965	nuclear membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000034329

View Gene Order

ENSBTAG00000012068

Not yet available

Pathways

NETPATH

REACTOME

REACT_160176

Cytosolic iron-sulfur cluster assembly pathway

REACT_1763

Homologous DNA pairing and strand exchange pathway

REACT_1874

Homologous Recombination Repair pathway

REACT_2054

Double-Strand Break Repair pathway

REACT_1587

Homologous recombination repair of replication-independent double-strand breaks pathway

REACT_111217

Metabolism pathway

REACT_216

DNA Repair pathway

KEGG

INOH

PID NCI

fanconi_pathway

Fanconi anemia pathway

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.128903

RefSeq

NM_032043

HUGO

OMIM

CCDS

CCDS11631

HPRD

05797

IMGT

EMBL

GenPept

RNA Seq Atlas