InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FLI1

Summary

InnateDB Protein

IDBP-75952.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FLI1

Protein Name

Friend leukemia virus integration 1

Synonyms

EWSR2; SIC-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000281428

InnateDB Gene

IDBG-75950 (FLI1)

Protein Structure

UniProt Annotation

Function

Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'.

Subcellular Localization

Nucleus.

Disease Associations

Ewing sarcoma (ES) [MIM:612219]: A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving FLI1 is found in patients with Erwing sarcoma. Translocation t(11;22)(q24;q12) with EWSR1.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	25 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007599	hemostasis
GO:0009887	organ morphogenesis
GO:0030154	cell differentiation
GO:0045087	innate immune response (InnateDB)