Version 5.4
Homo sapiens Protein: S1PR2
Summary
InnateDB Protein IDBP-759886.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol S1PR2
Protein Name
Synonyms AGR16; EDG-5; EDG5; Gpcr13; H218; LPB2; S1P2;
Species Homo sapiens
Ensembl Protein ENSP00000466933
InnateDB Gene IDBG-730032 (S1PR2)
Protein Structure
UniProt Annotation
Function Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001664 G-protein coupled receptor binding
GO:0004930 G-protein coupled receptor activity
GO:0005178 integrin binding
GO:0008289 lipid binding
GO:0038036 sphingosine-1-phosphate receptor activity
Biological Process
GO:0000187 activation of MAPK activity
GO:0003376 sphingosine-1-phosphate signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0008284 positive regulation of cell proliferation
GO:0090394 negative regulation of excitatory postsynaptic membrane potential
GO:1903142 positive regulation of establishment of endothelial barrier
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001671 Melanocortin/ACTH receptor
IPR004061 Sphingosine 1-phosphate receptor
IPR004063 EDG-5 sphingosine 1-phosphate receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
PFAM PF00001
PF10320
PRINTS PR00237
PR00534
PR01523
PR01525
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95136
PhosphoSite PhosphoSite-O95136
TrEMBL A0A024R7B2
UniProt Splice Variant
Entrez Gene 9294
UniGene
RefSeq NP_004221
HUGO HGNC:3169
OMIM 605111
CCDS CCDS12229
HPRD
IMGT
EMBL AF034780 AY262688 BC069598 CH471106
GenPept AAC98919 AAH69598 AAP20652 EAW84081 EAW84082

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca