InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: S1PR2

Summary

InnateDB Gene

IDBG-730032.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

S1PR2

Gene Name

Sphingosine 1-phosphate receptor 2

Synonyms

AGR16; EDG-5; EDG5; Gpcr13; H218; LPB2; S1P2

Species

Homo sapiens

Ensembl Gene

ENSG00000267534

Encoded Proteins

IDBP-759886

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. This protein participates in sphingosine 1-phosphate-induced cell proliferation, survival, and transcriptional activation [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:10223844-10231272

Strand

Reverse strand

Band

p13.2

Transcripts

ENST00000590320

ENSP00000466933

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0004930	G-protein coupled receptor activity
GO:0005178	integrin binding
GO:0008289	lipid binding
GO:0038036	sphingosine-1-phosphate receptor activity

Biological Process

GO:0000187	activation of MAPK activity
GO:0003376	sphingosine-1-phosphate signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0090394	negative regulation of excitatory postsynaptic membrane potential
GO:1903142	positive regulation of establishment of endothelial barrier