InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STAT3

Summary

InnateDB Protein

IDBP-760155.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STAT3

Protein Name

Synonyms

ADMIO; APRF; HIES;

Species

Homo sapiens

Ensembl Protein

ENSP00000467985

InnateDB Gene

IDBG-50702 (STAT3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 340 experimentally validated interaction(s) in this database.
They are also associated with 144 interaction(s) predicted by orthology.

Experimentally validated
Total	340 [view]
Protein-Protein	285 [view]
Protein-DNA	53 [view]
Protein-RNA	1 [view]
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	144 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001103	RNA polymerase II repressing transcription factor binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004871	signal transducer activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019901	protein kinase binding
GO:0019903	protein phosphatase binding
GO:0044212	transcription regulatory region DNA binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001659	temperature homeostasis
GO:0001754	eye photoreceptor cell differentiation
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006606	protein import into nucleus
GO:0006928	cellular component movement
GO:0007165	signal transduction
GO:0007259	JAK-STAT cascade
GO:0007399	nervous system development
GO:0016032	viral process
GO:0016310	phosphorylation
GO:0019221	cytokine-mediated signaling pathway
GO:0019953	sexual reproduction
GO:0030522	intracellular receptor signaling pathway
GO:0032355	response to estradiol
GO:0032870	cellular response to hormone stimulus
GO:0042593	glucose homeostasis
GO:0042755	eating behavior
GO:0045087	innate immune response (InnateDB)
GO:0045747	positive regulation of Notch signaling pathway
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048708	astrocyte differentiation
GO:0060019	radial glial cell differentiation
GO:0060396	growth hormone receptor signaling pathway
GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway
GO:0070102	interleukin-6-mediated signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000980 SH2 domain
IPR008967 p53-like transcription factor, DNA-binding
IPR013799 STAT transcription factor, protein interaction
IPR013800 STAT transcription factor, all-alpha
IPR013801 STAT transcription factor, DNA-binding
IPR015988 STAT transcription factor, coiled coil

PFAM

PF00017
PF14633
PF02865
PF01017
PF02864

PRINTS

PR00401

PIRSF

SMART

SM00252
SM00964

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt