Homo sapiens Gene: STAT3
Summary
InnateDB Gene IDBG-50702.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STAT3
Gene Name signal transducer and activator of transcription 3 (acute-phase response factor)
Synonyms ADMIO; APRF; HIES;
Species Homo sapiens
Ensembl Gene ENSG00000168610
Encoded Proteins
signal transducer and activator of transcription 3 (acute-phase response factor)
signal transducer and activator of transcription 3 (acute-phase response factor)
signal transducer and activator of transcription 3 (acute-phase response factor)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
STAT3 is a transcription factor that mediates interleukin-10 (IL-10) cytokine signalling.
STAT3 and SRC have a role in the immunoregulation of dendritic cells (DCs) where apoptotic cells-induced inhibition of dendritic cells (DCs) requires MerTK-dependent activation of SRC and STAT3.
STAT3 mediates mucosa-protective and anti-inflammatory functions in epithelial and myeloid cells and promotes inflammation in T cells.
STAT3 binds to multiple genes involved in Th17 cell differentiation, cell activation, proliferation, and survival, regulating both expression, epigenetic modifications, and targets the T cell function in inflammation and homeostasis.
STAT3 is an essential mediator of emergency granulopoiesis via its regulation of transcription factors CEBPA and CEBPB that direct granulocyte colony-stimulating factor (G-CSF)-responsive myeloid progenitor expansion.
STAT3 is a negative regulator of type I IFN-mediated anti-viral responses. (Demonstrated in mouse)
In alveolar epithelium, IL22 upregulates DEFB4A gene expression via STAT3.
MIR29A inhibits IL10-induced cytokine release by targeting JAK-STAT3 in monocytes during sepsis.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Stat3 is a negative regulator of type I IFN-mediated anti-viral responses.
[Mus musculus] STAT3 mediates protein transport and secretion in hepatocytes during the acute phase of pneumonia.
[Mus musculus] Stat3 mediates protection against intestinal infection by inducing innate lymphoid cell derived-Il22.
[Mus musculus] Stat3 is required for maximal Osm-induced lung Cxcl5 expression and subsequent neutrophil recruitment during bacterial pneumonia.
Entrez Gene
Summary The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:42313324-42388568
Strand Reverse strand
Band q21.2
Transcripts
ENST00000264657 ENSP00000264657
ENST00000389272 ENSP00000373923
ENST00000404395 ENSP00000384943
ENST00000462286
ENST00000491272
ENST00000462269
ENST00000471989
ENST00000498330
ENST00000478276
ENST00000590776
ENST00000588969 ENSP00000467985
ENST00000585360
ENST00000585517 ENSP00000467000
ENST00000588065 ENSP00000467173
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 340 experimentally validated interaction(s) in this database.
They are also associated with 144 interaction(s) predicted by orthology.
Experimentally validated
Total 340 [view]
Protein-Protein 285 [view]
Protein-DNA 53 [view]
Protein-RNA 1 [view]
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 144 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001103 RNA polymerase II repressing transcription factor binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004871 signal transducer activity
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031730 CCR5 chemokine receptor binding
GO:0035259 glucocorticoid receptor binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046983 protein dimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001659 temperature homeostasis
GO:0001754 eye photoreceptor cell differentiation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006606 protein import into nucleus
GO:0006928 cellular component movement
GO:0006953 acute-phase response
GO:0007165 signal transduction
GO:0007259 JAK-STAT cascade
GO:0007399 nervous system development
GO:0008283 cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0010033 response to organic substance
GO:0014070 response to organic cyclic compound
GO:0016032 viral process
GO:0016310 phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0019827 stem cell maintenance
GO:0019953 sexual reproduction
GO:0030522 intracellular receptor signaling pathway
GO:0032355 response to estradiol
GO:0032870 cellular response to hormone stimulus
GO:0034097 response to cytokine
GO:0040014 regulation of multicellular organism growth
GO:0042493 response to drug
GO:0042593 glucose homeostasis
GO:0042755 eating behavior
GO:0043434 response to peptide hormone
GO:0045087 innate immune response (InnateDB)
GO:0045471 response to ethanol
GO:0045747 positive regulation of Notch signaling pathway
GO:0045820 negative regulation of glycolytic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048708 astrocyte differentiation
GO:0060019 radial glial cell differentiation
GO:0060396 growth hormone receptor signaling pathway
GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway
GO:0060548 negative regulation of cell death
GO:0070102 interleukin-6-mediated signaling pathway
GO:2001223 negative regulation of neuron migration
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005743 mitochondrial inner membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
AndrogenReceptor pathway
Notch pathway
EGFR1 pathway
KitReceptor pathway
BCR pathway
IL1 pathway
IL2 pathway
IL3 pathway
IL4 pathway
IL5 pathway
IL6 pathway
IL-7 pathway
IL9 pathway
Leptin pathway
TSH pathway
TSLP pathway
Prolactin pathway
IL11 pathway
Oncostatin_M pathway
REACTOME
Signaling by FGFR in disease pathway
Signalling to STAT3 pathway
Signaling by FGFR mutants pathway
Cellular responses to stress pathway
Developmental Biology pathway
Signalling by NGF pathway
Transcriptional regulation of pluripotent stem cells pathway
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation pathway
Cytokine Signaling in Immune system pathway
Signaling by FGFR1 mutants pathway
Signaling by SCF-KIT pathway
Interleukin-6 signaling pathway
Signal Transduction pathway
Immune System pathway
Downstream signal transduction pathway
Cellular Senescence pathway
Growth hormone receptor signaling pathway
Signaling by Interleukins pathway
NGF signalling via TRKA from the plasma membrane pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Signaling by PDGF pathway
Signaling by FGFR1 fusion mutants pathway
Disease pathway
Signaling by Leptin pathway
KEGG
Chemokine signaling pathway pathway
Jak-STAT signaling pathway pathway
Adipocytokine signaling pathway pathway
Toxoplasmosis pathway
Hepatitis C pathway
Pathways in cancer pathway
Pancreatic cancer pathway
Acute myeloid leukemia pathway
INOH
IL-23 signaling pathway
IFN alpha signaling pathway
IL-10 signaling pathway
BMP2 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
IL-6 signaling pathway
LIF signaling pathway
TPO signaling pathway
PID BIOCARTA
Il 6 signaling pathway [Biocarta view]
Role of erbb2 in signal transduction and oncology [Biocarta view]
Pdgf signaling pathway [Biocarta view]
Stat3 signaling pathway [Biocarta view]
Il22 soluble receptor signaling pathway [Biocarta view]
Tpo signaling pathway [Biocarta view]
Bioactive peptide induced signaling pathway [Biocarta view]
Egf signaling pathway [Biocarta view]
Erk1/erk2 mapk signaling pathway [Biocarta view]
PID NCI
IL2-mediated signaling events
IL27-mediated signaling events
IL12-mediated signaling events
Signaling events mediated by PTP1B
ErbB1 downstream signaling
IL12 signaling mediated by STAT4
Signaling events mediated by HDAC Class I
Notch-mediated HES/HEY network
Neurotrophic factor-mediated Trk receptor signaling
RAC1 signaling pathway
FGF signaling pathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
Signaling events mediated by TCPTP
IL23-mediated signaling events
ErbB2/ErbB3 signaling events
PDGFR-beta signaling pathway
IL6-mediated signaling events
IFN-gamma pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.463059
RefSeq NM_003150 NM_139276 NM_213662 XM_005257616 XM_005257617 XM_005257618
HUGO
OMIM
CCDS CCDS32656 CCDS32657 CCDS59288
HPRD 00026
IMGT
EMBL
GenPept
RNA Seq Atlas