Version 5.4
Homo sapiens Protein: KANK2
Summary
InnateDB Protein IDBP-761390.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KANK2
Protein Name
Synonyms ANKRD25; MXRA3; SIP;
Species Homo sapiens
Ensembl Protein ENSP00000467029
InnateDB Gene IDBG-28941 (KANK2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
Experimentally validated
Total 23 [view]
Protein-Protein 22 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006915 apoptotic process
GO:0008285 negative regulation of cell proliferation
GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway
GO:0043069 negative regulation of programmed cell death
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID
InterPro IPR002110 Ankyrin repeat
IPR020683 Ankyrin repeat-containing domain
IPR021939 Kank N-terminal motif
PFAM PF00023
PF13606
PF11929
PF12796
PF12075
PRINTS PR01415
PIRSF
SMART SM00248
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q63ZY3
PhosphoSite PhosphoSite-Q63ZY3
TrEMBL Q9NXX5
UniProt Splice Variant
Entrez Gene 25959
UniGene Hs.742251
RefSeq
HUGO HGNC:29300
OMIM 614610
CCDS
HPRD 12463
IMGT
EMBL AB040951 AB284125 AC009000 AC011485 AK000011 AK002094 AK023332 AY639929 BC082762 BC098105 BC098286 BC098312 BC105989 CH471106
GenPept AAH82762 AAH98105 AAH98286 AAH98312 AAI05990 AAT57879 BAA90882 BAA92081 BAA96042 BAB14531 BAG06864 EAW84177

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca