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InnateDB Protein
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IDBP-76255.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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IPPK
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Protein Name
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inositol 1,3,4,5,6-pentakisphosphate 2-kinase
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000364672
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InnateDB Gene
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IDBG-76251 (IPPK)
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Protein Structure
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| Function |
Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis. {ECO:0000269PubMed:12084730, ECO:0000269PubMed:15967797}.
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| Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
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| Disease Associations |
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| Tissue Specificity |
Ubiquitously expressed, with high expression in heart, brain, testis and placenta. {ECO:0000269PubMed:12084730}.
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
| Experimentally validated |
| Total |
3
[view]
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| Protein-Protein |
2
[view]
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| Protein-DNA |
1
[view]
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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Molecular Function |
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| Biological Process |
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| Cellular Component |
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| PDB ID |
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| InterPro |
IPR009286
Inositol-pentakisphosphate 2-kinase
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| PFAM |
PF06090
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-Q9H8X2
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| TrEMBL |
X6R9A6
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| UniProt Splice Variant |
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| Entrez Gene |
64768
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| UniGene |
Hs.674179
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| RefSeq |
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| HUGO |
HGNC:14645
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| OMIM |
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| CCDS |
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| HPRD |
10799
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| IMGT |
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| EMBL |
AL137074
AL157827
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| GenPept |
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Version 5.4