Version 5.4
Homo sapiens Gene: IPPK
Summary
InnateDB Gene IDBG-76251.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IPPK
Gene Name inositol 1,3,4,5,6-pentakisphosphate 2-kinase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000127080
Encoded Proteins
IDBP-76253
inositol 1,3,4,5,6-pentakisphosphate 2-kinase
IDBP-76255
inositol 1,3,4,5,6-pentakisphosphate 2-kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a kinase that phosphorylates position 2 of inositol-1,3,4,5,6-pentakisphosphate to form inositol-1,2,3,4,5,6-hexakisphosphate (InsP6). InsP6 has a variety of functions, including stimulation of DNA repair, endocytosis, and mRNA export. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:92613184-92670265
Strand Reverse strand
Band q22.31
Transcripts
ENST00000287996 ENSP00000287996
ENST00000375522 ENSP00000364672
ENST00000486841
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
GO:0035299 inositol pentakisphosphate 2-kinase activity
Biological Process
GO:0016310 phosphorylation
GO:0043647 inositol phosphate metabolic process
GO:0044281 small molecule metabolic process
GO:0052746 inositol phosphorylation
Cellular Component
GO:0005622 intracellular
GO:0005654 nucleoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021385
View Gene Order
ENSBTAG00000011859
Not yet available
Pathways
NETPATH
REACTOME
REACT_150188
Synthesis of pyrophosphates in the cytosol pathway
REACT_150275
Synthesis of IPs in the nucleus pathway
REACT_150154
Inositol phosphate metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00562
Inositol phosphate metabolism pathway
hsa04070
Phosphatidylinositol signaling system pathway
INOH
PID NCI
Cross-References
SwissProt Q9H8X2
TrEMBL X6R9A6
UniProt Splice Variant
Entrez Gene 64768
UniGene Hs.459896 Hs.674179
RefSeq NM_022755 XM_006717235
HUGO HGNC:14645
OMIM
CCDS CCDS6699
HPRD
IMGT
EMBL AF351202 AF520811 AK023225 AK024267 AL137074 AL157827 BC026154
GenPept AAH26154 AAK69692 AAM75353 BAB14476 BAB14866 CAI12586 CAI12593 CAI14368
RNA Seq Atlas 64768

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca