InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UBA52

Summary

InnateDB Protein

IDBP-763405.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBA52

Protein Name

Synonyms

CEP52; HUBCEP52; L40; RPL40;

Species

Homo sapiens

Ensembl Protein

ENSP00000470419

InnateDB Gene

IDBG-281627 (UBA52)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 63 experimentally validated interaction(s) in this database.

Experimentally validated
Total	63 [view]
Protein-Protein	63 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000086	G2/M transition of mitotic cell cycle
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000187	activation of MAPK activity
GO:0000209	protein polyubiquitination
GO:0000278	mitotic cell cycle
GO:0002224	toll-like receptor signaling pathway
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0005975	carbohydrate metabolic process
GO:0005978	glycogen biosynthetic process
GO:0006006	glucose metabolic process
GO:0006281	DNA repair
GO:0006351	transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006412	translation
GO:0006413	translational initiation
GO:0006414	translational elongation
GO:0006415	translational termination
GO:0006464	cellular protein modification process
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0006915	apoptotic process
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007219	Notch signaling pathway
GO:0007220	Notch receptor processing
GO:0007249	I-kappaB kinase/NF-kappaB signaling
GO:0007254	JNK cascade
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0016197	endosomal transport
GO:0019058	viral life cycle
GO:0019068	virion assembly
GO:0019082	viral protein processing
GO:0019083	viral transcription
GO:0019221	cytokine-mediated signaling pathway
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0032479	regulation of type I interferon production
GO:0032480	negative regulation of type I interferon production
GO:0032481	positive regulation of type I interferon production
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034146	toll-like receptor 5 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0034166	toll-like receptor 10 signaling pathway
GO:0034220	ion transmembrane transport
GO:0035666	TRIF-dependent toll-like receptor signaling pathway
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042981	regulation of apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0044267	cellular protein metabolic process
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0050852	T cell receptor signaling pathway
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051403	stress-activated MAPK cascade
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0055085	transmembrane transport
GO:0061024	membrane organization
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway
GO:0071456	cellular response to hypoxia
GO:0075733	intracellular transport of virus
GO:0097190	apoptotic signaling pathway

Cellular Component

GO:0005654	nucleoplasm
GO:0005765	lysosomal membrane
GO:0005829	cytosol
GO:0005840	ribosome
GO:0005886	plasma membrane
GO:0010008	endosome membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0030666	endocytic vesicle membrane