Homo sapiens Gene: UBA52
Summary
InnateDB Gene IDBG-281627.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBA52
Gene Name ubiquitin A-52 residue ribosomal protein fusion product 1
Synonyms CEP52; HUBCEP52; L40; RPL40;
Species Homo sapiens
Ensembl Gene ENSG00000221983
Encoded Proteins
ubiquitin A-52 residue ribosomal protein fusion product 1
ubiquitin A-52 residue ribosomal protein fusion product 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Ubiquitin is a highly conserved nuclear and cytoplasmic protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein L40 at the C terminus, a C-terminal extension protein (CEP). Multiple processed pseudogenes derived from this gene are present in the genome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:18571730-18577550
Strand Forward strand
Band p13.11
Transcripts
ENST00000442744 ENSP00000388107
ENST00000430157 ENSP00000396910
ENST00000599595 ENSP00000471464
ENST00000595683 ENSP00000470419
ENST00000598814
ENST00000596272 ENSP00000472768
ENST00000594527 ENSP00000471991
ENST00000595158 ENSP00000471622
ENST00000598780 ENSP00000472545
ENST00000597451 ENSP00000473048
ENST00000596273 ENSP00000471062
ENST00000596304 ENSP00000472264
ENST00000599551 ENSP00000470507
ENST00000599256 ENSP00000472137
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 63 experimentally validated interaction(s) in this database.
Experimentally validated
Total 63 [view]
Protein-Protein 63 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000187 activation of MAPK activity
GO:0000209 protein polyubiquitination
GO:0000278 mitotic cell cycle
GO:0002224 toll-like receptor signaling pathway
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0005975 carbohydrate metabolic process
GO:0005978 glycogen biosynthetic process
GO:0006006 glucose metabolic process
GO:0006281 DNA repair
GO:0006351 transcription, DNA-templated
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006412 translation
GO:0006413 translational initiation
GO:0006414 translational elongation
GO:0006415 translational termination
GO:0006464 cellular protein modification process
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0006915 apoptotic process
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007219 Notch signaling pathway
GO:0007220 Notch receptor processing
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007254 JNK cascade
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0010467 gene expression
GO:0016032 viral process
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0016197 endosomal transport
GO:0019058 viral life cycle
GO:0019068 virion assembly
GO:0019082 viral protein processing
GO:0019083 viral transcription
GO:0019221 cytokine-mediated signaling pathway
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0032479 regulation of type I interferon production
GO:0032480 negative regulation of type I interferon production
GO:0032481 positive regulation of type I interferon production
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034146 toll-like receptor 5 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034166 toll-like receptor 10 signaling pathway
GO:0034220 ion transmembrane transport
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0044267 cellular protein metabolic process
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0050852 T cell receptor signaling pathway
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051403 stress-activated MAPK cascade
GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0055085 transmembrane transport
GO:0061024 membrane organization
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway
GO:0071456 cellular response to hypoxia
GO:0075733 intracellular transport of virus
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005654 nucleoplasm
GO:0005765 lysosomal membrane
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0022625 cytosolic large ribosomal subunit
GO:0030666 endocytic vesicle membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
DNA Replication pathway
Signaling by FGFR in disease pathway
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
PCP/CE pathway pathway
truncated APC mutants destabilize the destruction complex pathway
p53-Dependent G1/S DNA damage checkpoint pathway
Eukaryotic Translation Initiation pathway
Constitutive Signaling by NOTCH1 HD Domain Mutants pathway
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
G1 Phase pathway
Cellular responses to stress pathway
Transmembrane transport of small molecules pathway
p53-Independent G1/S DNA damage checkpoint pathway
Processing-defective Hh variants abrogate ligand secretion pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
MyD88 dependent cascade initiated on endosome pathway
FCERI mediated NF-kB activation pathway
Oncogene Induced Senescence pathway
Signalling by NGF pathway
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
APC truncation mutants are not K63 polyubiquitinated pathway
Signaling by Hedgehog pathway
Signaling by EGFR in Cancer pathway
AMER1 mutants destabilize the destruction complex pathway
Circadian Clock pathway
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon pathway
Influenza Infection pathway
SRP-dependent cotranslational protein targeting to membrane pathway
Disease pathway
p75NTR recruits signalling complexes pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Nonsense-Mediated Decay (NMD) pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Synthesis of DNA pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Signaling by WNT in cancer pathway
APC/C-mediated degradation of cell cycle proteins pathway
APC/C:Cdc20 mediated degradation of Cyclin B pathway
SCF-beta-TrCP mediated degradation of Emi1 pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Myoclonic epilepsy of Lafora pathway
beta-catenin independent WNT signaling pathway
TCR signaling pathway
AXIN missense mutants destabilize the destruction complex pathway
Vif-mediated degradation of APOBEC3G pathway
Regulation of mitotic cell cycle pathway
APC/C:Cdc20 mediated degradation of Securin pathway
Antiviral mechanism by IFN-stimulated genes pathway
Regulation of APC/C activators between G1/S and early anaphase pathway
Glycogen synthesis pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
NOTCH1 Intracellular Domain Regulates Transcription pathway
Signaling by Wnt pathway
Signaling by constitutively active EGFR pathway
Interleukin-3, 5 and GM-CSF signaling pathway
MyD88 cascade initiated on plasma membrane pathway
Mitotic G1-G1/S phases pathway
Signaling by NOTCH1 in Cancer pathway
Signaling by EGFR pathway
Cytokine Signaling in Immune system pathway
S Phase pathway
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) pathway
Metabolism of carbohydrates pathway
Downregulation of ERBB2:ERBB3 signaling pathway
Innate Immune System pathway
Signaling by ERBB4 pathway
Regulation of activated PAK-2p34 by proteasome mediated degradation pathway
Stimuli-sensing channels pathway
NF-kB is activated and signals survival pathway
IKK complex recruitment mediated by RIP1 pathway
IRAK1 recruits IKK complex pathway
Autodegradation of Cdh1 by Cdh1:APC/C pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Formation of a pool of free 40S subunits pathway
Stabilization of p53 pathway
NOTCH2 Activation and Transmission of Signal to the Nucleus pathway
APC truncation mutants have impaired AXIN binding pathway
Degradation of GLI2 by the proteasome pathway
Late Phase of HIV Life Cycle pathway
degradation of DVL pathway
GLI3 is processed to GLI3R by the proteasome pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Autodegradation of the E3 ubiquitin ligase COP1 pathway
Cyclin D associated events in G1 pathway
ER-Phagosome pathway pathway
Toll-Like Receptors Cascades pathway
Spry regulation of FGF signaling pathway
Degradation of beta-catenin by the destruction complex pathway
deactivation of the beta-catenin transactivating complex pathway
Fc epsilon receptor (FCERI) signaling pathway
p75 NTR receptor-mediated signalling pathway
Synthesis And Processing Of GAG, GAGPOL Polyproteins pathway
T41 mutants of beta-catenin aren't phosphorylated pathway
Degradation of GLI1 by the proteasome pathway
p75NTR signals via NF-kB pathway
Influenza Viral RNA Transcription and Replication pathway
Translation pathway
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
DNA Replication Pre-Initiation pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
G1/S Transition pathway
Apoptosis pathway
Signal Transduction pathway
TRAF6 mediated induction of TAK1 complex pathway
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation pathway
Interferon Signaling pathway
Separation of Sister Chromatids pathway
Hedgehog 'off' state pathway
MAP kinase activation in TLR cascade pathway
misspliced GSK3beta mutants stabilize beta-catenin pathway
Regulation of innate immune responses to cytosolic DNA pathway
S45 mutants of beta-catenin aren't phosphorylated pathway
Regulation of PLK1 Activity at G2/M Transition pathway
Hh ligand biogenesis disease pathway
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
Ubiquitin-dependent degradation of Cyclin D pathway
deletions in the AMER1 gene destabilize the destruction complex pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
Cell Cycle pathway
Antigen processing-Cross presentation pathway
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha pathway
AUF1 (hnRNP D0) destabilizes mRNA pathway
regulation of FZD by ubiquitination pathway
Endosomal Sorting Complex Required For Transport (ESCRT) pathway
Signaling by NOTCH2 pathway
Generic Transcription Pathway pathway
Activation of NF-kappaB in B cells pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
Signaling by NOTCH1 pathway
Activated NOTCH1 Transmits Signal to the Nucleus pathway
Eukaryotic Translation Termination pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
Metabolism of proteins pathway
Adaptive Immune System pathway
NOD1/2 Signaling Pathway pathway
Association of licensing factors with the pre-replicative complex pathway
Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway
Removal of licensing factors from origins pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Immune System pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
MyD88-independent cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
Ion channel transport pathway
Cellular response to hypoxia pathway
S33 mutants of beta-catenin aren't phosphorylated pathway
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 pathway
p53-Dependent G1 DNA Damage Response pathway
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling pathway
Signaling by NOTCH1 in Cancer pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
NRIF signals cell death from the nucleus pathway
truncations of AMER1 destabilize the destruction complex pathway
M Phase pathway
Cellular Senescence pathway
Cyclin E associated events during G1/S transition pathway
HIV Life Cycle pathway
Hedgehog ligand biogenesis pathway
Mitotic Anaphase pathway
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
Fanconi Anemia pathway pathway
Downregulation of TGF-beta receptor signaling pathway
TCF dependent signaling in response to WNT pathway
Signaling by Interleukins pathway
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Signaling by NOTCH pathway
G2/M Transition pathway
Cap-dependent Translation Initiation pathway
Downstream TCR signaling pathway
Switching of origins to a post-replicative state pathway
Asymmetric localization of PCP proteins pathway
Ubiquitin-dependent degradation of Cyclin D1 pathway
M/G1 Transition pathway
Interleukin-1 signaling pathway
degradation of AXIN pathway
TGFBR1 KD Mutants in Cancer pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
Regulation of the Fanconi anemia pathway pathway
Orc1 removal from chromatin pathway
Signaling by NOTCH1 pathway
Cell Cycle, Mitotic pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
Eukaryotic Translation Elongation pathway
TCF7L2 mutants don't bind CTBP pathway
HIV Infection pathway
EGFR downregulation pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Activated TLR4 signalling pathway
Loss of Function of TGFBR1 in Cancer pathway
Signaling by FGFR pathway
TGFBR1 LBD Mutants in Cancer pathway
Activated NOTCH1 Transmits Signal to the Nucleus pathway
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
ISG15 antiviral mechanism pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Class I MHC mediated antigen processing & presentation pathway
Influenza Life Cycle pathway
activated TAK1 mediates p38 MAPK activation pathway
CDT1 association with the CDC6:ORC:origin complex pathway
p53-Independent DNA Damage Response pathway
G1/S DNA Damage Checkpoints pathway
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
SCF(Skp2)-mediated degradation of p27/p21 pathway
Signaling by ERBB2 pathway
IRAK2 mediated activation of TAK1 complex pathway
Mitotic G2-G2/M phases pathway
Signal Transduction pathway
Metabolism pathway
Negative regulation of FGFR signaling pathway
Assembly Of The HIV Virion pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
TGF-beta receptor signaling activates SMADs pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
Downregulation of ERBB4 signaling pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Host Interactions of HIV factors pathway
Regulation of DNA replication pathway
Cytosolic sensors of pathogen-associated DNA pathway
Viral mRNA Translation pathway
Signaling by the B Cell Receptor (BCR) pathway
Oxidative Stress Induced Senescence pathway
CDK-mediated phosphorylation and removal of Cdc6 pathway
Vpu mediated degradation of CD4 pathway
Signaling by NOTCH pathway
Negative regulators of RIG-I/MDA5 signaling pathway
Peptide chain elongation pathway
Budding and maturation of HIV virion pathway
Membrane binding and targetting of GAG proteins pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Regulation of Apoptosis pathway
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
L13a-mediated translational silencing of Ceruloplasmin expression pathway
Gene Expression pathway
S37 mutants of beta-catenin aren't phosphorylated pathway
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
Disease pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
DNA Repair pathway
Glucose metabolism pathway
Glycogen storage diseases pathway
Assembly of the pre-replicative complex pathway
Signaling by TGF-beta Receptor Complex pathway
Membrane Trafficking pathway
Regulation of signaling by CBL pathway
Cell Cycle Checkpoints pathway
Mitotic Metaphase and Anaphase pathway
Downregulation of SMAD2/3:SMAD4 transcriptional activity pathway
KEGG
Ribosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P62987
TrEMBL A8CGI2 F5GZ39 J3QSA3 M0R1M6 M0R1V7 M0R2S1 Q3MIH3
UniProt Splice Variant
Entrez Gene 7311
UniGene Hs.5308 Hs.706079
RefSeq NM_001033930 NM_003333 XM_005260050 XM_005260051 XM_005260052 XM_005260053 XM_005260054 XM_006722871
HUGO HGNC:12458
OMIM 191321
CCDS CCDS12382
HPRD
IMGT
EMBL AB362574 AC005253 AC093484 AC126309 AF348700 AK314717 BC101830 BC101832 BC143668 CH471106 DQ479851 X56997 X56998 X56999 Y00361
GenPept AAC25582 AAI01831 AAI01833 AAI43669 AAK31162 ABE96835 BAF81539 BAG37261 CAA40312 CAA40313 CAA40314 CAA68439 EAW84715 EAW84716 EAW84717 EAW84718
RNA Seq Atlas 7311