Version 5.4
Homo sapiens Protein: FGF21
Summary
InnateDB Protein IDBP-763610.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FGF21
Protein Name
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000471477
InnateDB Gene IDBG-61149 (FGF21)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005104 fibroblast growth factor receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0008284 positive regulation of cell proliferation
GO:0010988 regulation of low-density lipoprotein particle clearance
GO:0045716 positive regulation of low-density lipoprotein particle receptor biosynthetic process
GO:0046326 positive regulation of glucose import
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR002209 Fibroblast growth factor family
IPR008996 Cytokine, IL-1-like
IPR028142 IL-1 family/FGF family
PFAM
PRINTS PR00263
PR00262
PIRSF
SMART SM00442
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NSA1
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 26291
UniGene Hs.735856
RefSeq XP_005258788
HUGO HGNC:3678
OMIM 609436
CCDS CCDS12734
HPRD 09447
IMGT
EMBL AB021975 AY359086 BC018404 CH471177 DQ847413
GenPept AAH18404 AAQ89444 ABI75345 BAA99415 EAW52402

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca