Homo sapiens Protein: YWHAE
Summary
InnateDB Protein IDBP-763713.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol YWHAE
Protein Name
Synonyms 14-3-3E; HEL2; KCIP-1; MDCR; MDS;
Species Homo sapiens
Ensembl Protein ENSP00000461762
InnateDB Gene IDBG-14629 (YWHAE)
Protein Structure
UniProt Annotation
Function Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
Subcellular Localization Cytoplasm {ECO:0000250}. Melanosome {ECO:0000269PubMed:12042314, ECO:0000269PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 439 experimentally validated interaction(s) in this database.
They are also associated with 142 interaction(s) predicted by orthology.
Experimentally validated
Total 439 [view]
Protein-Protein 433 [view]
Protein-DNA 5 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 142 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015459 potassium channel regulator activity
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0023026 MHC class II protein complex binding
GO:0042826 histone deacetylase binding
GO:0044325 ion channel binding
GO:0044822 poly(A) RNA binding
GO:0046982 protein heterodimerization activity
GO:0050815 phosphoserine binding
GO:0051219 phosphoprotein binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0003064 regulation of heart rate by hormone
GO:0006915 apoptotic process
GO:0016032 viral process
GO:0021762 substantia nigra development
GO:0035329 hippo signaling
GO:0035556 intracellular signal transduction
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0060306 regulation of membrane repolarization
GO:0061024 membrane organization
GO:0086013 membrane repolarization during cardiac muscle cell action potential
GO:0086091 regulation of heart rate by cardiac conduction
GO:0097190 apoptotic signaling pathway
GO:0097193 intrinsic apoptotic signaling pathway
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1901016 regulation of potassium ion transmembrane transporter activity
GO:1902309 negative regulation of peptidyl-serine dephosphorylation
Cellular Component
GO:0005829 cytosol
GO:0016020 membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0042470 melanosome
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000308 14-3-3 protein
IPR023410 14-3-3 domain
PFAM PF00244
PRINTS PR00305
PIRSF PIRSF000868
SMART SM00101
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P62258
PhosphoSite PhosphoSite-P62258
TrEMBL B7ZA86
UniProt Splice Variant
Entrez Gene 7531
UniGene Hs.704053
RefSeq
HUGO HGNC:12851
OMIM 605066
CCDS
HPRD 05457
IMGT
EMBL AB017103 AK128785 AK295260 AK316185 AK316201 AY883089 BC000179 BC001440 BT007161 CH471108 U20972 U28936 U43399 U43430 U54778
GenPept AAA75301 AAC50175 AAC50625 AAC50710 AAD00026 AAH00179 AAH01440 AAP35825 AAX68683 BAA32538 BAG54733 BAG58249 BAH14556 BAH14572 EAW90628 EAW90629