InnateDB Protein
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IDBP-763713.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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YWHAE
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Protein Name
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Synonyms
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14-3-3E; HEL2; KCIP-1; MDCR; MDS;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000461762
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InnateDB Gene
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IDBG-14629 (YWHAE)
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Protein Structure
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Function |
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Melanosome {ECO:0000269PubMed:12042314, ECO:0000269PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 439 experimentally validated interaction(s) in this database.
They are also associated with 142 interaction(s) predicted by orthology.
Experimentally validated |
Total |
439
[view]
|
Protein-Protein |
433
[view]
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Protein-DNA |
5
[view]
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
142 [view]
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Molecular Function |
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Biological Process |
GO:0000086
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G2/M transition of mitotic cell cycle
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GO:0000278
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mitotic cell cycle
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GO:0003064
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regulation of heart rate by hormone
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GO:0006915
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apoptotic process
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GO:0016032
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viral process
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GO:0021762
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substantia nigra development
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GO:0035329
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hippo signaling
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GO:0035556
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intracellular signal transduction
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GO:0043281
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regulation of cysteine-type endopeptidase activity involved in apoptotic process
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GO:0045087
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innate immune response (InnateDB)
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GO:0048011
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neurotrophin TRK receptor signaling pathway
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GO:0060306
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regulation of membrane repolarization
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GO:0061024
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membrane organization
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GO:0086013
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membrane repolarization during cardiac muscle cell action potential
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GO:0086091
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regulation of heart rate by cardiac conduction
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GO:0097190
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apoptotic signaling pathway
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GO:0097193
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intrinsic apoptotic signaling pathway
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GO:1900740
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positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
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GO:1901016
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regulation of potassium ion transmembrane transporter activity
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GO:1902309
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negative regulation of peptidyl-serine dephosphorylation
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Cellular Component |
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PDB ID |
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InterPro |
IPR000308
14-3-3 protein
IPR023410
14-3-3 domain
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PFAM |
PF00244
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PRINTS |
PR00305
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PIRSF |
PIRSF000868
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SMART |
SM00101
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TIGRFAMs |
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Modification |
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SwissProt |
P62258
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PhosphoSite |
PhosphoSite-P62258
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TrEMBL |
B7ZA86
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UniProt Splice Variant |
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Entrez Gene |
7531
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UniGene |
Hs.704053
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RefSeq |
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HUGO |
HGNC:12851
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OMIM |
605066
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CCDS |
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HPRD |
05457
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IMGT |
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EMBL |
AB017103
AK128785
AK295260
AK316185
AK316201
AY883089
BC000179
BC001440
BT007161
CH471108
U20972
U28936
U43399
U43430
U54778
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GenPept |
AAA75301
AAC50175
AAC50625
AAC50710
AAD00026
AAH00179
AAH01440
AAP35825
AAX68683
BAA32538
BAG54733
BAG58249
BAH14556
BAH14572
EAW90628
EAW90629
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