Version 5.4
Homo sapiens Protein: CACTIN
Summary
InnateDB Protein IDBP-763992.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CACTIN
Protein Name
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000465751
InnateDB Gene IDBG-17610 (CACTIN)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0001933 negative regulation of protein phosphorylation
GO:0007275 multicellular organismal development
GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032688 negative regulation of interferon-beta production
GO:0032717 negative regulation of interleukin-8 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0034122 negative regulation of toll-like receptor signaling pathway
GO:0045087 innate immune response (InnateDB)
GO:0060339 negative regulation of type I interferon-mediated signaling pathway
GO:0071222 cellular response to lipopolysaccharide
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
GO:0071013 catalytic step 2 spliceosome
Protein Structure and Domains
PDB ID
InterPro IPR018816 Cactin, central domain
IPR019134 Cactin, C-terminal
PFAM PF10312
PF09732
PRINTS
PIRSF
SMART SM01050
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WUQ7
PhosphoSite PhosphoSite-Q8WUQ7
TrEMBL K7EIU6
UniProt Splice Variant
Entrez Gene 58509
UniGene Hs.729778
RefSeq
HUGO HGNC:29938
OMIM
CCDS CCDS45920
HPRD
IMGT
EMBL AC005175 AC005542 AF155102 AY917150 BC004262 BC019848 CH471139
GenPept AAC24305 AAC32903 AAD42868 AAH04262 AAH19848 AAX84551 EAW69298

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca