InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GAS7

Summary

InnateDB Protein

IDBP-764424.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GAS7

Protein Name

Synonyms

MLL/GAS7;

Species

Homo sapiens

Ensembl Protein

ENSP00000464240

InnateDB Gene

IDBG-29999 (GAS7)

Protein Structure

UniProt Annotation

Function

May play a role in promoting maturation and morphological differentiation of cerebellar neurons.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Note=A chromosomal aberration involving GAS7 is found in acute myeloid leukemia. Translocation t(11;17)(q23;p13) with KMT2A/MLL1.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.

Experimentally validated
Total	38 [view]
Protein-Protein	38 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0007050	cell cycle arrest

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001060 FCH domain
IPR001202 WW domain

PFAM

PF00611
PF00397

PRINTS

PIRSF

SMART

SM00055
SM00456

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O60861

PhosphoSite

PhosphoSite-O60861

TrEMBL

J3QS26

UniProt Splice Variant

Entrez Gene

8522

UniGene

Hs.618996

RefSeq

NP_958836

HUGO

HGNC:4169

OMIM

603127

CCDS

CCDS42263

HPRD

16011

IMGT

EMBL

AB007854 AC000003 AC005747 AC026591 AC083783 AC107938 AF231998 AJ224876 AK292987 AK293755 AK315162 AY327406 BC001152 BC006454 BT006891 CH471108

GenPept

AAG26332 AAH01152 AAH06454 AAP35537 AAP92798 BAA23690 BAF85676 BAG37606 BAH11588 CAA12177 EAW90011 EAW90012 EAW90013