Version 5.4
Homo sapiens Protein: FLT3LG
Summary
InnateDB Protein IDBP-765017.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FLT3LG
Protein Name
Synonyms FL; FLT3L;
Species Homo sapiens
Ensembl Protein ENSP00000469613
InnateDB Gene IDBG-62803 (FLT3LG)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005125 cytokine activity
GO:0030971 receptor tyrosine kinase binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0007165 signal transduction
GO:0008284 positive regulation of cell proliferation
GO:0030098 lymphocyte differentiation
GO:0032825 positive regulation of natural killer cell differentiation
GO:0035162 embryonic hemopoiesis
Cellular Component
GO:0005615 extracellular space
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031233 intrinsic to external side of plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR004213 Flt3 ligand
IPR009079 Four-helical cytokine-like, core
PFAM PF02947
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P49771
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 2323
UniGene Hs.734589
RefSeq NP_001191432
HUGO HGNC:3766
OMIM 600007
CCDS CCDS12767
HPRD 02477
IMGT
EMBL AC010619 AK301136 BC028001 BC126293 BC136464 U03858 U04806 U29874
GenPept AAA17999 AAA19825 AAA90949 AAA90950 AAH28001 AAI26294 AAI36465 BAG62728

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca