Version 5.4
Homo sapiens Gene: FLT3LG
Summary
InnateDB Gene IDBG-62803.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FLT3LG
Gene Name fms-related tyrosine kinase 3 ligand
Synonyms FL; FLT3L
Species Homo sapiens
Ensembl Gene ENSG00000090554
Encoded Proteins
IDBP-62805
fms-related tyrosine kinase 3 ligand
IDBP-765017
IDBP-761824
IDBP-766120
IDBP-762157
IDBP-761643
IDBP-762817
IDBP-765832
IDBP-765958
IDBP-761798
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]).[supplied by OMIM, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:49474207-49486231
Strand Forward strand
Band q13.33
Transcripts
ENST00000204637 ENSP00000204637
ENST00000594009 ENSP00000469613
ENST00000595815
ENST00000595510 ENSP00000471226
ENST00000597914 ENSP00000473098
ENST00000600084 ENSP00000472628
ENST00000601800 ENSP00000471860
ENST00000598555 ENSP00000469181
ENST00000593422
ENST00000598472
ENST00000596435 ENSP00000469942
ENST00000600429 ENSP00000470453
ENST00000597551 ENSP00000468977
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005125 cytokine activity
GO:0030971 receptor tyrosine kinase binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0007165 signal transduction
GO:0008284 positive regulation of cell proliferation
GO:0030098 lymphocyte differentiation
GO:0032825 positive regulation of natural killer cell differentiation
GO:0035162 embryonic hemopoiesis
Cellular Component
GO:0005615 extracellular space
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031233 intrinsic to external side of plasma membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
hsa04640
Hematopoietic cell lineage pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa05200
Pathways in cancer pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL M0R2K0
UniProt Splice Variant
Entrez Gene 2323
UniGene Hs.428 Hs.734589
RefSeq XM_005258685 NM_001204502 NM_001204503 NM_001278637 NM_001278638 NM_001459 XM_005258681 XM_006723114
HUGO HGNC:3766
OMIM 600007
CCDS CCDS12767 CCDS62753
HPRD 02477
IMGT
EMBL AC010619
GenPept
RNA Seq Atlas 2323

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca