Version 5.4
Homo sapiens Protein: DEDD2
Summary
InnateDB Protein IDBP-765668.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DEDD2
Protein Name
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000470082
InnateDB Gene IDBG-53904 (DEDD2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 18 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030159 receptor signaling complex scaffold activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006396 RNA processing
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0016075 rRNA catabolic process
GO:0019725 cellular homeostasis
GO:0030262 apoptotic nuclear changes
GO:0035556 intracellular signal transduction
GO:0042981 regulation of apoptotic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005730 nucleolus
Protein Structure and Domains
PDB ID
InterPro IPR001875 Death effector domain
IPR011029 Death-like domain
PFAM PF01335
PRINTS
PIRSF
SMART SM00031
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WXF8
PhosphoSite PhosphoSite-Q8WXF8
TrEMBL M0QYK9
UniProt Splice Variant
Entrez Gene 162989
UniGene Hs.515432
RefSeq NP_001257543
HUGO HGNC:24450
OMIM
CCDS CCDS12597
HPRD 10868
IMGT
EMBL AC006486 AC010247 AC098778 AF443591 AF457575 AK075328 AY125488 BC013372 BC027930
GenPept AAH13372 AAH27930 AAL48220 AAM10835 AAM95240 BAC11551

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca