Version 5.4
Homo sapiens Protein: GTF2H4
Summary
InnateDB Protein IDBP-76889.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GTF2H4
Protein Name general transcription factor IIH, polypeptide 4, 52kDa
Synonyms P52; TFB2; TFIIH;
Species Homo sapiens
Ensembl Protein ENSP00000365493
InnateDB Gene IDBG-237742 (GTF2H4)
Protein Structure
UniProt Annotation
Function Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
Experimentally validated
Total 39 [view]
Protein-Protein 34 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004003 ATP-dependent DNA helicase activity
GO:0004672 protein kinase activity
GO:0005515 protein binding
GO:0008094 DNA-dependent ATPase activity
GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity
Biological Process
GO:0000718 nucleotide-excision repair, DNA damage removal
GO:0006200 ATP catabolic process
GO:0006281 DNA repair
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006289 nucleotide-excision repair
GO:0006355 regulation of transcription, DNA-templated
GO:0006360 transcription from RNA polymerase I promoter
GO:0006361 transcription initiation from RNA polymerase I promoter
GO:0006362 transcription elongation from RNA polymerase I promoter
GO:0006363 termination of RNA polymerase I transcription
GO:0006366 transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0006370 7-methylguanosine mRNA capping
GO:0006468 protein phosphorylation
GO:0010467 gene expression
GO:0016032 viral process
GO:0032508 DNA duplex unwinding
GO:0050434 positive regulation of viral transcription
Cellular Component
GO:0000439 core TFIIH complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005675 holo TFIIH complex
Protein Structure and Domains
PDB ID
InterPro IPR004598 Transcription factor TFIIH subunit p52/Tfb2
PFAM PF03849
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q92759
PhosphoSite PhosphoSite-Q92759
TrEMBL
UniProt Splice Variant
Entrez Gene 2968
UniGene Hs.485070
RefSeq
HUGO HGNC:4658
OMIM 601760
CCDS CCDS34386
HPRD 03456
IMGT
EMBL AB088103 AB103609 AB202101 AL773541 AY124590 BA000025 BC004935 BC016302 BT007321 BX927194 CH471081 CR759747 CR936875 Y07595
GenPept AAH04935 AAH16302 AAM64222 AAP35985 BAB63317 BAC54936 BAE78622 BAF31271 CAA68870 CAI18452 CAQ06761 CAQ09772 CAQ10923 EAX03347

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca