InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GTF2H4

Summary

InnateDB Gene

IDBG-237742.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GTF2H4

Gene Name

general transcription factor IIH, polypeptide 4, 52kDa

Synonyms

P52; TFB2; TFIIH

Species

Homo sapiens

Ensembl Gene

ENSG00000213780

Encoded Proteins

IDBP-76883

general transcription factor IIH, polypeptide 4, 52kDa

IDBP-76889

general transcription factor IIH, polypeptide 4, 52kDa

IDBP-370045

general transcription factor IIH, polypeptide 4, 52kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:30908184-30914106

Strand

Forward strand

Band

p21.33

Transcripts

ENST00000259895	ENSP00000259895
ENST00000376316	ENSP00000365493
ENST00000453897	ENSP00000410160
ENST00000487746
ENST00000483318
ENST00000475845

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.

Experimentally validated
Total	39 [view]
Protein-Protein	34 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004003	ATP-dependent DNA helicase activity
GO:0004672	protein kinase activity
GO:0005515	protein binding
GO:0008094	DNA-dependent ATPase activity
GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity

Biological Process

GO:0000718	nucleotide-excision repair, DNA damage removal
GO:0006200	ATP catabolic process
GO:0006281	DNA repair
GO:0006283	transcription-coupled nucleotide-excision repair
GO:0006289	nucleotide-excision repair
GO:0006355	regulation of transcription, DNA-templated
GO:0006360	transcription from RNA polymerase I promoter
GO:0006361	transcription initiation from RNA polymerase I promoter
GO:0006362	transcription elongation from RNA polymerase I promoter
GO:0006363	termination of RNA polymerase I transcription
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0006370	7-methylguanosine mRNA capping
GO:0006468	protein phosphorylation
GO:0010467	gene expression
GO:0016032	viral process
GO:0032508	DNA duplex unwinding
GO:0050434	positive regulation of viral transcription

Cellular Component

GO:0000439	core TFIIH complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005675	holo TFIIH complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000001524

View Gene Order

ENSBTAG00000046757

Not yet available

Pathways

NETPATH

NetPath_2

AndrogenReceptor pathway

REACTOME

REACT_1074

RNA Polymerase I Transcription Termination pathway

REACT_2204

RNA Polymerase I Chain Elongation pathway

REACT_1913

RNA Polymerase I Promoter Escape pathway

REACT_953

RNA Polymerase I Transcription Initiation pathway

REACT_1470

mRNA Capping pathway

REACT_1655

RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway

REACT_22107

RNA Polymerase II Pre-transcription Events pathway

REACT_1845

Formation of RNA Pol II elongation complex pathway

REACT_846

Formation of the Early Elongation Complex pathway

REACT_833

RNA Polymerase II Transcription Elongation pathway

REACT_2089

RNA Polymerase II Promoter Escape pathway

REACT_1851

RNA Polymerase II Transcription Initiation pathway

REACT_834

RNA Polymerase II Transcription Initiation And Promoter Clearance pathway

REACT_975

RNA Pol II CTD phosphorylation and interaction with CE pathway

REACT_22201

Formation of HIV elongation complex in the absence of HIV Tat pathway

REACT_6332

HIV Transcription Initiation pathway

REACT_6253

RNA Polymerase II HIV Promoter Escape pathway

REACT_6319

Formation of the HIV-1 Early Elongation Complex pathway

REACT_6346

Formation of HIV-1 elongation complex containing HIV-1 Tat pathway

REACT_6162

Tat-mediated elongation of the HIV-1 transcript pathway

REACT_6237

RNA Pol II CTD phosphorylation and interaction with CE pathway

REACT_6233

Transcription of the HIV genome pathway

REACT_6361

Late Phase of HIV Life Cycle pathway

REACT_1941

Formation of transcription-coupled NER (TC-NER) repair complex pathway

REACT_2222

Dual incision reaction in TC-NER pathway

REACT_1628

Transcription-coupled NER (TC-NER) pathway

REACT_311

Dual incision reaction in GG-NER pathway

REACT_257

Formation of incision complex in GG-NER pathway

REACT_1309

RNA Polymerase I Transcription pathway

REACT_200857

Epigenetic regulation of gene expression pathway

REACT_1974

RNA Polymerase I Promoter Clearance pathway

REACT_200856

NoRC negatively regulates rRNA expression pathway

REACT_2253

Global Genomic NER (GG-NER) pathway

REACT_6274

HIV Transcription Elongation pathway

REACT_1366

RNA Polymerase II Transcription pathway

REACT_6256

HIV Life Cycle pathway

REACT_6185

HIV Infection pathway

REACT_21352

RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway

REACT_1826

Nucleotide Excision Repair pathway

REACT_71

Gene Expression pathway

REACT_116125

Disease pathway

REACT_216

DNA Repair pathway

REACT_200834

Negative epigenetic regulation of rRNA expression pathway

KEGG

hsa03022

Basal transcription factors pathway

hsa03420

Nucleotide excision repair pathway

INOH

PID NCI

Cross-References

SwissProt

Q92759

TrEMBL

UniProt Splice Variant

Entrez Gene

2968

UniGene

Hs.485070

RefSeq

NM_001517

HUGO

HGNC:4658

OMIM

601760

CCDS

CCDS34386

HPRD

03456

IMGT

EMBL

AB088103 AB103609 AB202101 AL773541 AY124590 BA000025 BC004935 BC016302 BT007321 BX927194 CH471081 CR759747 CR936875 Y07595

GenPept

AAH04935 AAH16302 AAM64222 AAP35985 BAB63317 BAC54936 BAE78622 BAF31271 CAA68870 CAI18452 CAQ06761 CAQ09772 CAQ10923 EAX03347

RNA Seq Atlas

2968