Homo sapiens Gene: GTF2H4
Summary
InnateDB Gene IDBG-237742.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GTF2H4
Gene Name general transcription factor IIH, polypeptide 4, 52kDa
Synonyms P52; TFB2; TFIIH;
Species Homo sapiens
Ensembl Gene ENSG00000213780
Encoded Proteins
general transcription factor IIH, polypeptide 4, 52kDa
general transcription factor IIH, polypeptide 4, 52kDa
general transcription factor IIH, polypeptide 4, 52kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 6:30908184-30914106
Strand Forward strand
Band p21.33
Transcripts
ENST00000259895 ENSP00000259895
ENST00000376316 ENSP00000365493
ENST00000453897 ENSP00000410160
ENST00000487746
ENST00000483318
ENST00000475845
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
Experimentally validated
Total 39 [view]
Protein-Protein 34 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004003 ATP-dependent DNA helicase activity
GO:0004672 protein kinase activity
GO:0005515 protein binding
GO:0008094 DNA-dependent ATPase activity
GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity
Biological Process
GO:0000718 nucleotide-excision repair, DNA damage removal
GO:0006200 ATP catabolic process
GO:0006281 DNA repair
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006289 nucleotide-excision repair
GO:0006355 regulation of transcription, DNA-templated
GO:0006360 transcription from RNA polymerase I promoter
GO:0006361 transcription initiation from RNA polymerase I promoter
GO:0006362 transcription elongation from RNA polymerase I promoter
GO:0006363 termination of RNA polymerase I transcription
GO:0006366 transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0006370 7-methylguanosine mRNA capping
GO:0006468 protein phosphorylation
GO:0010467 gene expression
GO:0016032 viral process
GO:0032508 DNA duplex unwinding
GO:0050434 positive regulation of viral transcription
Cellular Component
GO:0000439 core TFIIH complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005675 holo TFIIH complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
AndrogenReceptor pathway
REACTOME
RNA Polymerase II Transcription Initiation pathway
Formation of the Early Elongation Complex pathway
Transcription-coupled NER (TC-NER) pathway
RNA Polymerase I Transcription pathway
RNA Polymerase I Promoter Escape pathway
Formation of incision complex in GG-NER pathway
Late Phase of HIV Life Cycle pathway
RNA Pol II CTD phosphorylation and interaction with CE pathway
Epigenetic regulation of gene expression pathway
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway
Dual incision reaction in GG-NER pathway
RNA Polymerase I Promoter Clearance pathway
NoRC negatively regulates rRNA expression pathway
Global Genomic NER (GG-NER) pathway
Formation of HIV-1 elongation complex containing HIV-1 Tat pathway
RNA Polymerase I Transcription Termination pathway
Tat-mediated elongation of the HIV-1 transcript pathway
Formation of RNA Pol II elongation complex pathway
HIV Transcription Elongation pathway
Formation of HIV elongation complex in the absence of HIV Tat pathway
RNA Polymerase II Transcription pathway
RNA Polymerase II HIV Promoter Escape pathway
Dual incision reaction in TC-NER pathway
RNA Polymerase II Promoter Escape pathway
HIV Life Cycle pathway
RNA Polymerase II Pre-transcription Events pathway
mRNA Capping pathway
RNA Polymerase I Chain Elongation pathway
RNA Polymerase I Transcription Initiation pathway
Transcription of the HIV genome pathway
RNA Pol II CTD phosphorylation and interaction with CE pathway
RNA Polymerase II Transcription Elongation pathway
HIV Infection pathway
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
Formation of transcription-coupled NER (TC-NER) repair complex pathway
HIV Transcription Initiation pathway
Formation of the HIV-1 Early Elongation Complex pathway
Nucleotide Excision Repair pathway
Gene Expression pathway
Disease pathway
RNA Polymerase II Transcription Initiation And Promoter Clearance pathway
DNA Repair pathway
Negative epigenetic regulation of rRNA expression pathway
KEGG
Basal transcription factors pathway
Nucleotide excision repair pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.485070
RefSeq NM_001517
HUGO
OMIM
CCDS CCDS34386
HPRD 03456
IMGT
EMBL
GenPept
RNA Seq Atlas