InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FBP2

Summary

InnateDB Protein

IDBP-76916.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FBP2

Protein Name

fructose-1,6-bisphosphatase 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000364486

InnateDB Gene

IDBG-76914 (FBP2)

Protein Structure

UniProt Annotation

Function

Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate. {ECO:0000269PubMed:17350621, ECO:0000269PubMed:18214967}.

Subcellular Localization

Cell junction {ECO:0000250}. Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere, Z line. Note=In neonatal cardiomyocytes, distributed throughout the cytosol, accumulating in the intercalated disks which occur at the Z line of cardiomyocytes and connect adjacent cells, and also located in the nucleus; dissociates from the Z line following an increase in cytosolic Ca(2+) concentration (By similarity). In muscle precursor cells, localizes predominantly to the nucleus and to a lesser extent to the cytoplasm at the proliferative phase, while mainly localizing to the cytoplasm at the differentiation phase (By similarity). Colocalizes with ALDOA and alpha-actinin on both sides of the Z line of skeletal muscle; dissociates rapidly from the Z line following an increase in cytosolic Ca(2+) concentration. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in skeletal muscle (at protein level). {ECO:0000269PubMed:12507293}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0042132	fructose 1,6-bisphosphate 1-phosphatase activity
GO:0042578	phosphoric ester hydrolase activity
GO:0046872	metal ion binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006000	fructose metabolic process
GO:0006006	glucose metabolic process
GO:0006094	gluconeogenesis
GO:0016311	dephosphorylation
GO:0044281	small molecule metabolic process
GO:0046854	phosphatidylinositol phosphorylation

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0030018	Z disc
GO:0030054	cell junction
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000146 Fructose-1,6-bisphosphatase class 1/Sedoheputulose-1,7-bisphosphatase
IPR000760 Inositol monophosphatase
IPR023079 Sedoheptulose-1,7-bisphosphatase
IPR028343 Fructose-1,6-bisphosphatase

PFAM

PF00316
PF00459

PRINTS

PR00377
PR01958
PR00115

PIRSF

PIRSF000904
PIRSF500210

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt