Homo sapiens Protein: FBP2 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-76916.5 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | FBP2 | ||||||||||||||||||
Protein Name | fructose-1,6-bisphosphatase 2 | ||||||||||||||||||
Synonyms | |||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000364486 | ||||||||||||||||||
InnateDB Gene | IDBG-76914 (FBP2) | ||||||||||||||||||
Protein Structure |
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UniProt Annotation | |||||||||||||||||||
Function | Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate. {ECO:0000269PubMed:17350621, ECO:0000269PubMed:18214967}. | ||||||||||||||||||
Subcellular Localization | Cell junction {ECO:0000250}. Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere, Z line. Note=In neonatal cardiomyocytes, distributed throughout the cytosol, accumulating in the intercalated disks which occur at the Z line of cardiomyocytes and connect adjacent cells, and also located in the nucleus; dissociates from the Z line following an increase in cytosolic Ca(2+) concentration (By similarity). In muscle precursor cells, localizes predominantly to the nucleus and to a lesser extent to the cytoplasm at the proliferative phase, while mainly localizing to the cytoplasm at the differentiation phase (By similarity). Colocalizes with ALDOA and alpha-actinin on both sides of the Z line of skeletal muscle; dissociates rapidly from the Z line following an increase in cytosolic Ca(2+) concentration. {ECO:0000250}. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | Expressed in skeletal muscle (at protein level). {ECO:0000269PubMed:12507293}. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR000146
Fructose-1,6-bisphosphatase class 1/Sedoheputulose-1,7-bisphosphatase IPR000760 Inositol monophosphatase IPR023079 Sedoheptulose-1,7-bisphosphatase IPR028343 Fructose-1,6-bisphosphatase |
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PFAM |
PF00316
PF00459 |
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PRINTS |
PR00377
PR01958 PR00115 |
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PIRSF |
PIRSF000904
PIRSF500210 |
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SMART | |||||||||||||||||||
TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | O00757 | ||||||||||||||||||
PhosphoSite | PhosphoSite-O00757 | ||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 8789 | ||||||||||||||||||
UniGene | Hs.61255 | ||||||||||||||||||
RefSeq | NP_003828 | ||||||||||||||||||
HUGO | HGNC:3607 | ||||||||||||||||||
OMIM | 603027 | ||||||||||||||||||
CCDS | CCDS6711 | ||||||||||||||||||
HPRD | 04322 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AL161728 BC113632 BC117477 CR536483 Y10812 | ||||||||||||||||||
GenPept | AAI13633 AAI17478 CAA71772 CAG38722 CAH72694 | ||||||||||||||||||