Homo sapiens Protein: FBP2
Summary
InnateDB Protein IDBP-76916.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBP2
Protein Name fructose-1,6-bisphosphatase 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000364486
InnateDB Gene IDBG-76914 (FBP2)
Protein Structure
UniProt Annotation
Function Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate. {ECO:0000269PubMed:17350621, ECO:0000269PubMed:18214967}.
Subcellular Localization Cell junction {ECO:0000250}. Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere, Z line. Note=In neonatal cardiomyocytes, distributed throughout the cytosol, accumulating in the intercalated disks which occur at the Z line of cardiomyocytes and connect adjacent cells, and also located in the nucleus; dissociates from the Z line following an increase in cytosolic Ca(2+) concentration (By similarity). In muscle precursor cells, localizes predominantly to the nucleus and to a lesser extent to the cytoplasm at the proliferative phase, while mainly localizing to the cytoplasm at the differentiation phase (By similarity). Colocalizes with ALDOA and alpha-actinin on both sides of the Z line of skeletal muscle; dissociates rapidly from the Z line following an increase in cytosolic Ca(2+) concentration. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in skeletal muscle (at protein level). {ECO:0000269PubMed:12507293}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity
GO:0042578 phosphoric ester hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006000 fructose metabolic process
GO:0006006 glucose metabolic process
GO:0006094 gluconeogenesis
GO:0016311 dephosphorylation
GO:0044281 small molecule metabolic process
GO:0046854 phosphatidylinositol phosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0030018 Z disc
GO:0030054 cell junction
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000146 Fructose-1,6-bisphosphatase class 1/Sedoheputulose-1,7-bisphosphatase
IPR000760 Inositol monophosphatase
IPR023079 Sedoheptulose-1,7-bisphosphatase
IPR028343 Fructose-1,6-bisphosphatase
PFAM PF00316
PF00459
PRINTS PR00377
PR01958
PR00115
PIRSF PIRSF000904
PIRSF500210
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O00757
PhosphoSite PhosphoSite-O00757
TrEMBL
UniProt Splice Variant
Entrez Gene 8789
UniGene Hs.61255
RefSeq NP_003828
HUGO HGNC:3607
OMIM 603027
CCDS CCDS6711
HPRD 04322
IMGT
EMBL AL161728 BC113632 BC117477 CR536483 Y10812
GenPept AAI13633 AAI17478 CAA71772 CAG38722 CAH72694