Homo sapiens Gene: FBP2
Summary
InnateDB Gene IDBG-76914.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBP2
Gene Name fructose-1,6-bisphosphatase 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000130957
Encoded Proteins
fructose-1,6-bisphosphatase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a gluconeogenesis regulatory enzyme which catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:94558720-94593793
Strand Reverse strand
Band q22.32
Transcripts
ENST00000375337 ENSP00000364486
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity
GO:0042578 phosphoric ester hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006000 fructose metabolic process
GO:0006006 glucose metabolic process
GO:0006094 gluconeogenesis
GO:0016311 dephosphorylation
GO:0044281 small molecule metabolic process
GO:0046854 phosphatidylinositol phosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0030018 Z disc
GO:0030054 cell junction
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Myoclonic epilepsy of Lafora pathway
Metabolism of carbohydrates pathway
Gluconeogenesis pathway
Metabolism pathway
Disease pathway
Glucose metabolism pathway
Glycogen storage diseases pathway
KEGG
Glycolysis / Gluconeogenesis pathway
Pentose phosphate pathway pathway
Fructose and mannose metabolism pathway
Insulin signaling pathway pathway
INOH
Pentose phosphate cycle pathway
Glycolysis Gluconeogenesis pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt O00757
TrEMBL
UniProt Splice Variant
Entrez Gene 8789
UniGene Hs.61255
RefSeq NM_003837
HUGO HGNC:3607
OMIM 603027
CCDS CCDS6711
HPRD 04322
IMGT
EMBL AL161728 BC113632 BC117477 CR536483 Y10812
GenPept AAI13633 AAI17478 CAA71772 CAG38722 CAH72694
RNA Seq Atlas 8789